Stalk mechanism of vesicle fusion
Stalk mechanism of vesicle fusion
复制标题
囊泡融合的茎机制
DOI：
--
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Y. Chizmadzhev
中科院分区：
文献类型：
--
作者：
M. Kozlov;S. Leikin;L. Chernomordik;V. Markin;Y. Chizmadzhev
从理论上探讨了囊泡单层融合引起的分离双层破裂的机理。单分子层融合的茎机制，假设两个相互作用的膜之间的茎的形成和扩展被认为是。茎的演化导致了体系中分离双层的形成和机械张力的出现。这种张力导致分离双层的破裂和亲水孔的形成。机械张力和亲水性孔隙能之间的竞争定义了接触双层破裂的标准。张力随外膜单层的负自发曲率Kso的绝对值的增加而增加。孔边缘能随着内膜单层的正自发曲率Ksi的增加而减小。计算了导致双层膜分离破裂的内外单分子膜自发曲率的关系。结果表明，只要膜单分子层的自发曲率具有相反的符号：K50 <0，Ksi<0，这种方法是可能的。有关的融合过程的实验数据进行了分析。
AbstractÅ mechanism for rupture of a separating bilayer, resulting from vesicle monolayer fusion is investigated theoretically. The stalk mechanism of monolayer fusion, assuming the formation and expansion of a stalk between two interacting membranes is considered. The stalk evolution leads to formation of a separating bilayer and mechanical tension appearance in the system. This tension results in rupture of the separating bilayer and hydrophilic pore formation. Competition between the mechanical tension and hydrophilic pore energy defines the criteria of contacting bilayer rupture. The tension increases with an increase of the absolute value of the negative spontaneous curvature of the outer membrane monolayer, Kso. The pore edge energy decreases with an increase of the positive spontaneous curvature of the inner membrane monolayer, Ksi. The relations of spontaneous curvatures of outer and inner monolayers, leading to separating bilayer rupture, is calculated. It is demonstrated that his process is possible, provided spontaneous curvatures of membrane monolayers have opposite signs: Kso<0, Ksi<0. Experimental data concerning the fusion process are analysed.
影响因子：
2.9
作者：
DUZGUNES, N;STRAUBINGER, RM;PAPAHADJOPOULOS, D
通讯作者：
PAPAHADJOPOULOS, D