Hemodynamic assessment of the development and rupture of intracranial aneurysms using computational simulations.
Hemodynamic assessment of the development and rupture of intracranial aneurysms using computational simulations.
复制标题
使用计算模拟对颅内动脉瘤的发展和破裂进行血流动力学评估。
DOI：
10.1080/01616412.1995.11740357
复制
发表时间：
1995
影响因子：
1.9
通讯作者：
William J. Powers
中科院分区：
文献类型：
--
作者：
S. Chitanvis;G. Hademenos;William J. Powers
颅内动脉瘤表现为血管壁薄弱区域内的囊状突起，破裂后会造成严重的神经系统风险。动脉瘤发展和破裂阶段的主要因素是血流动力学及其对动脉瘤壁的降解作用。利用计算机模拟技术研究了完全发育的动脉瘤内的壁动力学和血流动力学。为了研究壁动力学，将动脉瘤建模为具有线性弹性和塑性（粘弹性）壁行为的球壳。该模型对描述它的生物物理参数的敏感性将有助于定量评估动脉瘤破裂和蛛网膜下腔出血的诱发因素。对刚性壁球形动脉瘤进行了流体动力学模拟。我们观察到的发展和运动的环形旋涡内的横向囊。我们还通过在动脉瘤瘤颈附近放置一个裂口来模拟破裂的动脉瘤。流动模式显示血液在流动的初始阶段流出，但随着内部压力下降，此后不久显示血液流入。这些结果得到了临床观察结果的证实，即在动脉瘤内观察到湍流，如杂音减少所证明的。
Intracranial aneurysms manifest themselves as sacculations within a weakened region of the vessel wall and pose substantial neurological risks upon rupture. A primary factor in the development and rupture stages of an aneurysm is hemodynamics and its degrading effects on the aneurysm wall. Wall dynamics and hemodynamics within a fully developed aneurysm were investigated using computational simulation techniques. To study wall dynamics, the aneurysm was modeled as a thing spherical shell with linearly elastic and plastic (viscoelastic) wall behavior. The sensitivity of this model to the biophysical parameters which describe it will assist in the quantitative assessment of factors predisposing to aneurysm rupture and subarachnoid hemorrhage. Flow dynamics simulations were performed for spherical aneurysms with rigid walls. We observed the development and motion of an annular vortex within the lateral sacculation. We also simulated a ruptured aneurysm by placing a tear near the neck of the aneurysm. Flow patterns showed blood flowing out during the initial stages of the flow, but displayed an inflow of blood soon thereafter, as the internal pressure dropped. These results are substantiated by the clinical observations that turbulent flow is observed within the aneurysm as evidenced by reduced bruits.