Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC
Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC
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DOI：
10.1016/j.nucmedbio.2008.04.006
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发表时间：
2008-08-01
影响因子：
3.1
通讯作者：
Salvo, Diana
中科院分区：
文献类型：
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作者：
Asti, Mattia;De Pietri, Giovanni;Salvo, Diana
简介：使用 Ga-68-DOTATOC 和 PET/CT 大大增强了表达生长抑素受体的肿瘤的成像。方法：在这项工作中，评估了 Ge-68/Ge-68 发生器洗脱液的纯化方法和适合临床使用的 Ga-68-DOTATOC 的生产方法。将发生器洗脱液纯化并在 HCl/丙酮介质中的阳离子交换柱上浓缩。通过 ICP-Ms 研究了该程序从 Ga-68 溶液中消除金属杂质的效果。通过放射性薄层色谱法和伽马射线光谱法评估放射性示踪剂的质量。结果：Ga-68-DOTATOC 制剂 (n=33) 的平均合成产率为 59.3 +/- 2.8%（未校正衰减），批次活性范围 > 95% 的 Fe(III)、Zn(II) 和 Mn(II) 从溶液中消除。结论：采用该方法生产的Ga-68-DOTATOC可有效用于核医学部门的PET评估。 (C) 2008 Elsevier Inc. 保留所有权利。
Introduction: Imaging of somatostatin receptor expressing tumors has been greatly enhanced by the use of Ga-68-DOTATOC and PET/CT.Methods: In this work, a purification method for the Ge-68/Ge-68 generator eluate and a method to produce Ga-68-DOTATOC suitable for clinical use were evaluated. The generator eluate was purified and concentrated on a cation-exchange cartridge in HCl/acetone media. The efficacy of this procedure in eliminating metal impurities from the Ga-68 soultion was investigated by ICP-Ms. The radiotracer quality was evaluated by radio-TLC, and gamma-ray spectrometry.Resutls: Ga-68-DOTATOC preparations (n=33) were carried out with a mean synthesis yield of 59.3 +/- 2.8% (not corrected for decay) and a batch activity ranging from >95% of the Fe(III), Zn(II) and Mn(II) were eliminated from the solution.Conclusions: Ga-68-DOTATOC produced with this method can be efficiently used in nuclear medicine departments for PET evaluations. (C) 2008 Elsevier Inc. All rights reserved.