DNA demethylation by TDG.
DNA demethylation by TDG.
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TDG 进行 DNA 去甲基化。
DOI：
10.2217/epi.12.36
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发表时间：
2012-08
期刊：
影响因子：
3.8
通讯作者：
Bellacosa A
中科院分区：
文献类型：
--
作者：
Dalton SR;Bellacosa A
长期以来，DNA甲基化一直被认为是哺乳动物中一种非常稳定的DNA修饰，只能通过在没有再甲基化的情况下进行复制来去除，即仅仅通过稀释这种表观遗传标记（所谓的被动DNA去甲基化）。然而，近年来，大量研究揭示了哺乳动物DNA去甲基化活性过程的存在，并在发育和转录调控中发挥重要作用，从而揭示了DNA去甲基化活性的分子机制。在这里，我们回顾了最近的文献，重点介绍了碱基切除修复，特别是胸腺嘧啶DNA糖基化酶在活性DNA去甲基化中的重要作用。
DNA methylation has long been considered a very stable DNA modification in mammals that could only be removed by replication in the absence of re-methylation, i.e. by mere dilution of this epigenetic mark (so-called passive DNA demethylation). However, in recent years, a significant number of studies have revealed the existence of active processes of DNA demethylation in mammals, with important roles in development and transcriptional regulation, allowing the molecular mechanisms of active DNA demethylation to be unraveled. Here we review the recent literature highlighting the prominent role played in active DNA demethylation by base excision repair and especially by Thymine DNA Glycosylase.