GABAergic mechanisms gate tactile discrimination learning
GABAergic mechanisms gate tactile discrimination learning
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DOI：
10.1097/00001756-200309150-00018
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发表时间：
2003-09-15
期刊：
影响因子：
1.7
通讯作者：
Tegenthoff, M
中科院分区：
文献类型：
--
作者：
Dinse, HR;Ragert, P;Tegenthoff, M
与调节突触可塑性的机制不同，知觉学习的药理学基础仍有待阐明。在这里，我们报告了一种特定形式的知觉学习受到GABA能机制的影响。我们通过Hebbian共同激活受试者右手食指尖端的皮肤来诱导知觉学习。在安慰剂条件下，共同激活的食指触觉两点辨别能力得到改善，但左手食指没有改善。这种增强可被GABA(A)受体激动剂劳拉西潘完全消除。在左手食指上没有发现药物效应，这表明药物本身对运动能力没有影响。结果表明，知觉学习受到药物门控的影响，其基本机制是调节和调节突触的可塑性。(C)2003年，里平科特·威廉姆斯·威尔金斯。
In contrast to mechanisms mediating synaptic plasticity, the pharmacological basis of perceptual learning remains to be clarified. Here we report that a specific form of perceptual learning is influenced by GABAergic mechanisms. We induced perceptual learning by Hebbian co-activation of the skin of the tip of the right index fingers in human subjects. Under placebo conditions, tactile 2-point discrimination was improved on the co-activated, but not on the left, index finger. This augmentation was completely eliminated by lorazepam, a GABA(A) receptor agonist. No drug effects were found on the left index finger indicating that the drugs had no effect per se on performance. The results demonstrate that perceptual learning is subject to pharmacological gating by basic mechanisms known to mediate and modulate synaptic plasticity. (C) 2003 Lippincott Williams Wilkins.