Juvenile recurrent parotitis: Soft foods contribute to the delayed development of salivary glands
Juvenile recurrent parotitis: Soft foods contribute to the delayed development of salivary glands
复制标题
青少年复发性腮腺炎：软食导致唾液腺发育迟缓
DOI：
10.1111/joor.12921
复制
发表时间：
2020
影响因子：
2.9
通讯作者：
Zheng Lingyan
中科院分区：
文献类型：
--
作者：
Wu Shufeng;Wang Baoli;Yu Chuangqi;Wang Zhijun;Xie Lisong;Fu Jiayao;Shi Huan;Zheng Lingyan
背景幼年性复发性腮腺炎(JRP)是仅次于腮腺炎的儿童唾液腺第二常见疾病。自从流行性腮腺炎疫苗接种普及以来，儿童患JRP的频率更高，其病因尚不清楚。目的探讨咀嚼是否与JRP的发病有关，以及软性饮食是否影响唾液腺的生长。方法调查2015~2018年JRP确诊儿童的饮食习惯和咀嚼效率，并与牙列正常儿童进行比较。小鼠从发育阶段开始就被喂以软饮食。检测腺体重量、唾液量、唾液淀粉酶、组织学和超微结构以及EGF、FGFR2和WNT3a的表达水平。结果JRP儿童偏爱软性食物，咀嚼效率明显低于正常儿童。当按体重正常化时，试验组的腺体重量、唾液量和唾液淀粉酶含量显著低于对照组。超微结构结果显示，实验组的腺泡细胞体积较小，含有较少的电子致密分泌颗粒。实验组小鼠唾液腺中EGF、FGFR2和WNT3a的表达水平明显低于对照组。结论软饮食确实通过咀嚼不足影响唾液腺，这可能是诱发JRP的主要因素之一。
BackgroundJuvenile recurrent parotitis (JRP) is the second‐most common childhood disease of the salivary glands after mumps. Since popularisation of mumps vaccination, children suffered from JRP more often, and the aetiology remains unclear. Chinese children had the habit of soft foods due to the special dietary habit of Asia.ObjectivesTo clarify whether mastication was related to the pathogenesis of JRP and whether the growth of salivary glands was influenced by soft diet.MethodsInvestigation of dietary habit and masticatory efficiency from 2015 to 2018 of children diagnosed with JRP compared with the normal children by the dentition. Mice had been fed a soft diet beginning in their development phase. The gland weight, amount of saliva, salivary amylase, histological and ultrastructural observation and the expression levels of EGF, FGFr2 and Wnt3a had been tested.ResultsThe JRP children preferred soft foods and had a significantly lower masticatory efficiency than do normal children. When normalised by body weight, the gland weight, amount of saliva and amount of salivary amylase in the experimental group were significantly lower. The ultrastructural results showed that the acinar cells in the experimental groups were smaller and contained fewer electron‐dense secretory granules than those in the control groups. The expression levels of EGF, FGFr2 and Wnt3a in the salivary glands of mice in the experimental groups were significantly lower than those of mice in the control groups.ConclusionThe soft diet indeed influenced the salivary gland through insufficient mastication, which could be one of the primary factors inducing JRP.