Synaptic drive at developing synapses: transient upregulation of kainate receptors.
Synaptic drive at developing synapses: transient upregulation of kainate receptors.
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DOI：
10.1002/dneu.20807
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发表时间：
2010-09-15
影响因子：
3
通讯作者：
Constantine-Paton, Martha
中科院分区：
文献类型：
--
作者：
van Zundert, Brigitte;Zhao, Jiang-Ping;Constantine-Paton, Martha
At the onset of a period of intense synaptic refinement initiated by synchronized eye-opening (EO), rapid changes in post-synaptic NMDA receptor and AMPA receptor currents (NMDARcs, AMPARcs) occur within the superficial visual layers of the rodent superior colliculus (sSC). Subsequently, evoked non-NMDARc amplitudes increase, but by 2 weeks after EO (AEO) they decrease significantly. Here, using whole-cell patch-clamp recording, we demonstrate that small, slowly desensitizing excitatory kainate receptor currents (KARcs) are responsible for the rise and subsequent fall in non-NMDARcs. The increase in KAR transmission parallels inhibitory GABAA responses that plateau at 7 days AEO. By 2 weeks AEO, KARcs are gone. AMPARcs remain unchanged during the appearance and disappearance of the KARcs, despite increases in sSC neuropil activity and continued refinement of inputs to individual sSC neurons. We suggest that in the interval of heightened activity, before SC inhibition matures, many AMPARcs desensitize and are relatively ineffective at relieving the Mg2+ block on NMDARs. This transient appearance of slowly desensitizing, long-duration KARcs may provide increased membrane depolarization necessary for NMDAR function and continuation of synaptic refinement.
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DOI：
10.1073/pnas.97.12.6838
发表时间：
2000-06-06
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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通讯作者：
Lund, R. D.
影响因子：
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作者：
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通讯作者：
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