Ghrelin and peptide YY in postpartum lactating and nonlactating women
Ghrelin and peptide YY in postpartum lactating and nonlactating women
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DOI：
10.3945/ajcn.2009.28616
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发表时间：
2010-02-01
影响因子：
7.1
通讯作者：
DeJonge, Lilian
中科院分区：
文献类型：
--
作者：
Larson-Meyer, D. Enette;Ravussin, Eric;DeJonge, Lilian
背景：流行病学研究表明，生育是许多女性发生肥胖的重要因素，母乳喂养可能具有保护作用。 Ghrelin 和肽 YY (PYY) 是参与食欲调节和能量稳态的肠道激素，是可能影响体重和肥胖的生物神经内分泌信号。 目的：本研究评估了与年龄、体重和肥胖相匹配的哺乳期和非哺乳期妇女之间，禁食或餐后 ghrelin 或 PYY 是否存在差异。设计：10 名产后哺乳期妇女（平均值 +/- SD：28.1 +/-产后 4-5 周，对 4.9 岁（69.2 +/- 11.3 公斤，35.4 +/- 6.6% 体脂）和 8 名非哺乳期妇女（28.8 +/- 7.6 岁，75.6 +/- 13.7 公斤，37.5 +/- 6.5% 体脂）进行了体重、身体成分和生长素释放肽测量。 PYY 对标准化膳食（350 kcal）的反应。七名从未怀孕的女性作为对照对象（年龄 29.7 +/- 4.1 岁，60.4 +/- 4.8 公斤，25.5 +/- 2.0% 体脂）。结果：进食后 Ghrelin 浓度下降，而 PYY 浓度显着升高 (P < 0.05)，但禁食或进餐引起的变化在哺乳期和非哺乳期妇女之间没有显着差异。空腹 ghrelin 浓度与体重指数相关（r = -0.53，P < 0.05），并且在产后显着低于对照女性（894.9 +/- 247.7 与 1316.9 +/- 241.0 pg/mL 相比），即使在调整体重指数后也是如此。结论：我们的数据不支持 ghrelin、PYY 或两者都是合理的观点。影响哺乳期间体重调节的神经内分泌信号。然而，他们认为，生长素释放肽可能会随着产后肥胖的增加而发生变化，并且可能在产后体重调节中发挥作用。美国临床营养杂志 2010；91：366-72。
Background: Epidemiologic studies suggest that childbearing is an important contributor to the development of obesity in many women and that breastfeeding may be protective. Ghrelin and peptide YY (PYY) are gut hormones involved in appetite regulation and energy homeostasis and are biological neuroendocrine signals that potentially affect body weight and adiposity.Objective: This study evaluated whether fasting or postprandial ghrelin or PYY is different between lactating and nonlactating postpartum women matched for age, body weight, and adiposity.Design: Ten postpartum lactating women (mean +/- SD: 28.1 +/- 4.9 y of age, 69.2 +/- 11.3 kg, 35.4 +/- 6.6% body fat) and 8 nonlactating women (28.8 +/- 7.6 y of age, 75.6 +/- 13.7 kg, 37.5 +/- 6.5% body fat) at 4-5 wk postpartum underwent measurements of body weight, body composition, and ghrelin and PYY responses to a standardized meal (350 kcal). Seven never-pregnant women served as control subjects (29.7 +/- 4.1 y of age, 60.4 +/- 4.8 kg, 25.5 +/- 2.0% body fat).Results: Ghrelin concentrations decreased, whereas PYY concentrations increased significantly (P < 0.05) in response to the meal, but fasting or meal-induced changes were not significantly different between lactating and nonlactating women. The fasting ghrelin concentration correlated with body mass index (r = -0.53, P < 0.05) and was significantly lower in postpartum than in control women (894.9 +/- 247.7 compared with 1316.9 +/- 241.0 pg/mL), even after adjustment for body mass index.Conclusions: Our data do not support the notion that ghrelin, PYY, or both are plausible neuroendocrine signals that influence body weight regulation during lactation. They suggest, however, that ghrelin may change with increased adiposity in the postpartum state and may potentially play a role in body weight regulation after child birth. Am J Clin Nutr 2010;91:366-72.