Night-shift work and risk of colorectal cancer in the Nurses' Health Study
Night-shift work and risk of colorectal cancer in the Nurses' Health Study
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DOI：
10.1093/jnci/95.11.825
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发表时间：
2003-06-04
影响因子：
10.3
通讯作者：
Colditz, GA
中科院分区：
文献类型：
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作者：
Schernhammer, ES;Laden, F;Colditz, GA
夜间暴露在光线下会抑制褪黑激素的生理性产生，褪黑激素是一种对肠癌具有抗增殖作用的激素。虽然观察性研究表明夜班工作与乳腺癌风险增加有关，但夜班工作对其他癌症风险的影响尚不清楚。我们在护士健康研究的女性参与者中前瞻性地检查了轮班夜班与结直肠癌风险之间的关系。我们记录了从1988年到1998年随访的78586名女性中602例结直肠癌病例。与从未轮班夜班的女性相比，轮班夜班1-14年或15年及以上的女性结直肠癌的多因素相对危险度分别为1.00（95%可信区间[CI] = 0.84至1.19）和1.35 (95% CI = 1.03至1.77)（p趋势= 0.04）。这些数据表明，每月至少三个晚上轮班工作15年或更长时间可能会增加女性患结肠直肠癌的风险。
Exposure to light at night suppresses the physiologic production of melatonin, a hormone that has antiproliferative effects on intestinal cancers. Although observational studies have associated night-shift work with an increased risk of breast cancer, the effect of night-shift work on the risk of other cancers is not known. We prospectively examined the relationship between working rotating night shifts and the risk of colorectal cancers among female participants in the Nurses' Health Study. We documented 602 incident cases of colorectal cancer among 78 586 women who were followed up from 1988 through 1998. Compared with women who never worked rotating night shifts, women who worked 1-14 years or 15 years or more on rotating night shifts had multivariate relative risks of colorectal cancer of 1.00 (95% confidence interval [CI] = 0.84 to 1.19) and 1.35 (95% CI = 1.03 to 1.77), respectively (P-trend = .04). These data suggest that working a rotating night shift at least three nights per month for 15 or more years may increase the risk of colorectal cancer in women.