Dietary lipids: an additional regulator of plasma levels of sex hormone binding globulin.
Dietary lipids: an additional regulator of plasma levels of sex hormone binding globulin.
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膳食脂质：性激素结合球蛋白血浆水平的额外调节剂。
DOI：
10.1210/jcem-64-5-1083
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
V.H.T. James
中科院分区：
文献类型：
--
作者：
Michael J. Reed;R. W. Cheng;M. Simmonds;William Richmond;V.H.T. James
本文研究了6名正常男性膳食脂肪摄入量对血浆性激素结合球蛋白（SHBG）、游离睾酮和胆固醇水平的影响。在食用高脂肪含量的饮食（大于100克脂肪/天）两周后，平均血浆胆固醇水平增加（p小于0.02），而平均SHBG水平下降（p小于0.02）。将饮食从高脂肪改变为低脂肪含量（低于20 g脂肪/天），持续两周，导致平均血浆胆固醇水平显著降低（p <0.001），而平均SHBG水平增加（p <0.01）。血浆SHBG的增加与游离睾酮分数和游离睾酮浓度的显著降低相关。在对照期内，从相同男性获得的血浆样本中未检测到显著变化。这项研究的结果表明，膳食脂质摄入量是一个额外的因素参与调节SHBG的血浆水平。
The effect of dietary lipid consumption on plasma levels of sex-hormone binding globulin (SHBG), free testosterone and cholesterol was studied in 6 normal men. After consuming a diet with a high fat content (greater than 100 g fat/day) for two weeks, the mean plasma cholesterol level increased (p less than 0.02) while the mean SHBG level decreased (p less than 0.02). Changing the diet from one with a high fat to low fat content (less than 20 g fat/day) for a further two week period resulted in a significant reduction in mean plasma cholesterol level (p less than 0.001) while the mean SHBG level increased (p less than 0.01). The increase in plasma SHBG was associated with a significant decrease in the free testosterone fraction and free testosterone concentration. No significant changes were detected in plasma samples obtained from the same men during a control period. The results from this study demonstrate that dietary lipid intake is an additional factor involved in the regulation of plasma levels of SHBG.
激素对人肝癌细胞系分泌类固醇结合蛋白的影响。
DOI：
10.1210/jcem-59-4-806
发表时间：
1984
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Rosner,W;Aden,DP;Khan,MS
通讯作者：
Khan,MS