Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders.
Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders.
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DOI：
10.1016/j.nicl.2023.103343
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发表时间：
2023
影响因子：
4.2
通讯作者：
Kiehl, Kent A.
中科院分区：
文献类型：
--
作者：
Allen, Corey H.;Shold, Jenna;Maurer, J. Michael;Reynolds, Brooke L.;Anderson, Nathaniel E.;Harenski, Carla L.;Harenski, Keith A.;Calhoun, Vince D.;Kiehl, Kent A.
关键词：
我们测试了童年创伤是否与异常的大脑连接有关。社区创伤与大部分副边缘区域的连通性改变有关。与自我报告相比，经过培训的评估者评估的重要性得到了强调。有童年创伤史的个体的特点是静息状态边缘和旁边缘功能网络连接异常。然而，尚不清楚特定的创伤亚型（即经历过的创伤与观察到的创伤或社区创伤）是否表现出不同的影响。本研究探讨了童年创伤的亚型（通过创伤检查表 [TCL] 2.0 进行评估）是否与网络内异常波动幅度和连接性（即网络内的功能一致性）以及被监禁青少年男性之间静息态网络的网络间连接性相关（n = 179）。通过 TCL 2.0 的主成分分析建立创伤亚型，并通过将组独立成分分析应用于静息态 fMRI 扫描来识别静息态网络。我们测试了儿童创伤亚型（即，测量经历过的创伤的 TCL 因子 1 和评估社区创伤的 TCL 因子 2）以及 TCL 总分与上述功能连接测量之间的关联。 TCL 因子 2 评分与认知控制、听觉和感觉运动网络的高频波动增加和网络内连接性增加相关，主要发生在旁边缘区域。 TCL 总分表现出与 TCL 因子 2 评分相似的神经生物学模式（加上视觉网络中异常的网络内连接），并且未发现 TCL 因子 1 存在显着关联。与之前对社区样本的分析一致，我们的结果表明，被监禁的少年男性中的童年创伤与多个网络之间的网络内波动幅度和连接异常相关，包括 主要是旁边缘区域。我们的结果强调了在评估与童年不良经历相关的神经生物学异常时考虑创伤性损失、观察到的创伤和社区创伤的重要性，以及与自我报告相比，经过培训的评估者创伤评估的价值。
We tested whether childhood trauma was associated with aberrant brain connectivity. Community trauma was associated with altered connectivity in mostly paralimbic areas. The importance of trained-rater assessments compared to self-report are highlighted. Individuals with history of childhood trauma are characterized by aberrant resting-state limbic and paralimbic functional network connectivity. However, it is unclear whether specific subtypes of trauma (i.e., experienced vs observed or community) showcase differential effects. This study examined whether subtypes of childhood trauma (assessed via the Trauma Checklist [TCL] 2.0) were associated with aberrant intra-network amplitude of fluctuations and connectivity (i.e., functional coherence within a network), and inter-network connectivity across resting-state networks among incarcerated juvenile males (n = 179). Subtypes of trauma were established via principal component analysis of the TCL 2.0 and resting-state networks were identified by applying group independent component analysis to resting-state fMRI scans. We tested the association of subtypes of childhood trauma (i.e., TCL Factor 1 measuring experienced trauma and TCL Factor 2 assessing community trauma), and TCL Total scores to the aforementioned functional connectivity measures. TCL Factor 2 scores were associated with increased high-frequency fluctuations and increased intra-network connectivity in cognitive control, auditory, and sensorimotor networks, occurring primarily in paralimbic regions. TCL Total scores exhibited similar neurobiological patterns to TCL Factor 2 scores (with the addition of aberrant intra-network connectivity in visual networks), and no significant associations were found for TCL Factor 1. Consistent with previous analyses of community samples, our results suggest that childhood trauma among incarcerated juvenile males is associated with aberrant intra-network amplitude of fluctuations and connectivity across multiple networks including predominately paralimbic regions. Our results highlight the importance of accounting for traumatic loss, observed trauma, and community trauma in assessing neurobiological aberrances associated with adverse experiences in childhood, as well as the value of trained-rater trauma assessments compared to self-report.
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影响因子：
4.6
作者：
Ermer, Elsa;Cope, Lora M.;Nyalakanti, Prashanth K.;Calhoun, Vince D.;Kiehl, Kent A.
通讯作者：
Kiehl, Kent A.
影响因子：
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作者：
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作者：
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作者：
Abou Elseoud, Ahmed;Littow, Hard;Kiviniemi, Vesa
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Kiviniemi, Vesa
DOI：
10.1037/tra0000423
发表时间：
2019-10-01
影响因子：
6.3
作者：
Dargis, Monika;Sitney, Miranda;Kiehl, Kent A.
通讯作者：
Kiehl, Kent A.