Intranigral muscimol attenuates electrographic signs of seizure activity induced by intravenous bicuculline in rats.
Intranigral muscimol attenuates electrographic signs of seizure activity induced by intravenous bicuculline in rats.
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黑质内蝇蕈醇可减弱大鼠静脉注射荷包牡丹碱诱发的癫痫发作活动的电图征象。
DOI：
10.1016/0014-2999(86)90242-6
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发表时间：
1986
影响因子：
5
通讯作者：
Gale,K
中科院分区：
文献类型：
--
作者：
Garant,D;Gale,K
在大鼠黑质（SN）内植入输液套管，并在颅内植入电极记录脑电图（EEG）。这些大鼠接受静脉注射荷包牡丹碱，产生重复的高电压尖峰和波复合体。与相同大鼠的黑质内盐水预处理相比，GABA激动剂蝇蕈醇的双侧黑质内输注预处理可使EEG癫痫活动的持续时间减少80%以上。黑质内蝇蕈醇的这种抗癫痫作用可能反映了SN输出对脑兴奋性的主要影响。
Rats were implanted with infusion cannulas in the substantia nigra((SN), and intracranial electrodes for recording the electroencephalogram (EEG). These rats received intravenous injections of bicuculline, producing repetitive high voltage spike-and-wave complexes. Pretreatment with bilateral intranigral infusions of the GABA agonist muscimol reduced the duration of EEG epileptic activity by over 80%, as compared to the effect of pretreatment with intranigral saline in the same rats. This antiepileptic effect of intranigral muscimol may reflect a primary influence of SN outputs on brain excitability.