Elevated serum levels of interleukin 21 are associated with disease severity in patients with psoriasis
Elevated serum levels of interleukin 21 are associated with disease severity in patients with psoriasis
复制标题
白细胞介素 21 血清水平升高与银屑病患者的疾病严重程度相关
DOI：
10.1111/j.1365-2133.2012.10899.x
复制
发表时间：
2012-07-01
影响因子：
10.3
通讯作者：
Wang, G.
中科院分区：
文献类型：
--
作者：
He, Z.;Jin, L.;Wang, G.
银屑病是一种涉及多种细胞因子的免疫性疾病。最近的研究表明，白细胞介素（IL）-21在多种炎症和自身免疫性疾病中起着重要作用。它在银屑病斑块中高度表达，并促进小鼠表皮的增殖。提示IL-21在银屑病的发病中起重要作用。然而，它是否在银屑病患者的外周血中升高并与疾病严重程度相关尚不清楚。目的检测银屑病患者血清IL-21水平，并探讨其与银屑病面积和严重程度指数（PASI）评分的相关性。采用酶联免疫吸附法检测37例银屑病患者和37例健康对照者血清IL-21水平。结果银屑病患者血清IL-21水平明显高于健康对照组（P <0.01），银屑病患者的PASI评分与血清IL-21水平呈负相关（P < 0.01）。银屑病患者血清IL-21水平与PASI评分呈正相关（r = 0.471，P < 0.01）。提示IL-21可能在银屑病发病中起重要作用。
Background Psoriasis is an immune disorder involving numerous cytokines. Recent studies have shown that interleukin (IL)-21 plays an important role in a variety of inflammatory and autoimmune diseases. It is highly expressed in psoriatic plaques and promotes the proliferation of epidermis in mice. It seems that IL-21 plays an important role in the pathogenesis of psoriasis. However, whether or not it is elevated in the peripheral blood of patients with psoriasis and is associated with disease severity is unclear. Therefore, our study focuses on serum IL-21 levels and their correlation with disease severity.Objectives To detect serum IL-21 levels in patients with psoriasis and investigate the correlation between these and the Psoriasis Area and Severity Index (PASI) scores.Methods Blood samples were collected from patients with plaque psoriasis and from healthy control subjects. Serum IL-21 levels were measured by enzyme-linked immunosorbent assay in 37 patients with psoriasis and 37 healthy controls. The PASI scores of patients with psoriasis and their correlation with serum IL-21 levels were evaluated.Results Serum IL-21 levels were higher in patients with psoriasis than in healthy controls (P < 0.01). Serum IL-21 levels were positively correlated with PASI scores in the patients with psoriasis (r = 0.471, P < 0.01).Conclusions Serum IL-21 levels in patients with psoriasis are elevated and positively correlate with PASI scores. These results indicate that IL-21 may play an important role in the pathogenesis of psoriasis.