Computational fluid dynamics of cerebral aneurysm coiling using high-resolution and high-energy synchrotron X-ray microtomography: comparison with the homogeneous porous medium approach.
Computational fluid dynamics of cerebral aneurysm coiling using high-resolution and high-energy synchrotron X-ray microtomography: comparison with the homogeneous porous medium approach.
复制标题
DOI：
10.1136/neurintsurg-2016-012479
复制
发表时间：
2017-08
影响因子：
4.8
通讯作者：
Aliseda A
中科院分区：
文献类型：
--
作者：
Levitt MR;Barbour MC;Rolland du Roscoat S;Geindreau C;Chivukula VK;McGah PM;Nerva JD;Morton RP;Kim LJ;Aliseda A
颅内动脉瘤的计算模型提供了血流动力学对动脉瘤生长、破裂和治疗结果的影响的洞察力。螺旋状动脉瘤的标准建模将复杂的线圈质量简化为填充动脉瘤囊的均质多孔介质。我们比较了由高分辨率成像模拟的螺旋动脉瘤和根据标准技术模拟的相同动脉瘤的血流动力学，以努力确定简化模型的误差来源。使用三维打印技术创建了两个未破裂动脉瘤的物理模型。使用与实际患者治疗中使用的相同的线圈对模型进行栓塞术，然后通过同步辐射X射线显微断层扫描获得线圈团块的高分辨率成像。使用特定于患者的边界条件对每个动脉瘤进行计算建模。使用简化的多孔介质或结合X射线成像的线圈表面来模拟线圈，并评估血流动力学变量的差异。对于这两个动脉瘤，螺旋CT的X射线微断层成像和合并到计算模型中都是成功的。与基于X射线的螺旋计算流体动力学模型相比，螺旋状动脉瘤血流动力学的多孔介质计算高估了动脉瘤内的血流，低估了振荡剪切指数和粘性耗散，高估或低估了壁面切应力(WSS)和WSS梯度。与包含复杂动脉瘤线圈几何形状的高分辨率同步X射线微断层成像的模型相比，使用多孔介质方法对螺旋状颅内动脉瘤进行计算建模可能会不准确地估计关键的血流动力学变量。
Computational modeling of intracranial aneurysms provides insights into the influence of hemodynamics on aneurysm growth, rupture, and treatment outcome. Standard modeling of coiled aneurysms simplifies the complex geometry of the coil mass into a homogeneous porous medium that fills the aneurysmal sac. We compare hemodynamics of coiled aneurysms modeled from high-resolution imaging with those from the same aneurysms modeled following the standard technique, in an effort to characterize sources of error from the simplified model. Physical models of two unruptured aneurysms were created using three-dimensional printing. The models were treated with coil embolization using the same coils as those used in actual patient treatment and then scanned by synchrotron X-ray microtomography to obtain high-resolution imaging of the coil mass. Computational modeling of each aneurysm was performed using patient-specific boundary conditions. The coils were modeled using the simplified porous medium or by incorporating the X-ray imaged coil surface, and the differences in hemodynamic variables were assessed. X-ray microtomographic imaging of coils and incorporation into computational models were successful for both aneurysms. Porous medium calculations of coiled aneurysm hemodynamics overestimated intraaneurysmal flow, underestimated oscillatory shear index and viscous dissipation, and over- or underpredicted wall shear stress (WSS) and WSS gradient compared with X-ray- based coiled computational fluid dynamics models. Computational modeling of coiled intracranial aneurysms using the porous medium approach may inaccurately estimate key hemodynamic variables compared with models incorporating high-resolution synchrotron X-ray microtomographic imaging of complex aneurysm coil geometry.