Presynaptic kainate receptors play different physiological roles in mossy fiber and associational-commissural synapses in CA3 of hippocampus from adult rats
Presynaptic kainate receptors play different physiological roles in mossy fiber and associational-commissural synapses in CA3 of hippocampus from adult rats
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DOI：
10.1016/s0304-3940(02)00865-0
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发表时间：
2002-10-11
影响因子：
2.5
通讯作者：
Stäubli, U
中科院分区：
文献类型：
--
作者：
Ji, ZX;Stäubli, U
在同一海马切片CA3上同时记录苔藓纤维（MF）和联合-联合（associationalcommissural）突触反应。低浓度的Kainate (KA)（50和100 nM）可逆地增加了MF突触的突触反应，降低了配对脉冲促进（PPF），而可逆地降低了Assoc-com突触的突触反应，增加了PPF。相同浓度的KA对CA1区的突触传递和长时程增强（LTP）的诱导表达没有影响。中频LTP部分阻断了KA对中频反应的影响。这些结果表明，KARs在MF和asc -com突触中都有突触前自受体的功能，但作用不同。(C) 2002爱思唯尔科学爱尔兰有限公司版权所有。
Mossy fiber (MF) and Associational-commissural (Assoc-com) synaptic responses were recorded simultaneously in CA3 from the same hippocampal slice. Low concentrations of Kainate (KA) (50 and 100 nM) reversibly increased the synaptic response and decreased the paired-pulse facilitation (PPF) in the MF synapse, while reversibly decreasing the synaptic response and increasing the PPF in the Assoc-com synapse. The same concentration of KA had no effect on synaptic transmission or the induction and expression of long-term potentiation (LTP) in area CA1. MF LTP partially occluded the effect of KA on MF responses. These results suggest that KARs function as presynaptic autoreceptors in both MF and Assoc-com synapses but play different roles. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.