Alkaloids from a deep ocean sediment-derived fungus Penicillium sp and their antitumor activities
Alkaloids from a deep ocean sediment-derived fungus Penicillium sp and their antitumor activities
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DOI：
10.1038/ja.2010.11
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发表时间：
2010-04-01
影响因子：
3.3
通讯作者：
Gu, Qianqun
中科院分区：
文献类型：
--
作者：
Du, Lin;Feng, Teng;Gu, Qianqun
从深海沉积物来源的青霉菌（Penicillium sp.）中分离得到4种新生物碱，包括两种新的黑曲霉素类似物黑曲霉素D（1）和E（2），以及两种新的哌嗪二酮类化合物roquefortine H（3）和I（4）。黑曲霉素D（1）和E（2）在咪唑基上具有前所未有的乙酸甲羟戊酸衍生侧链。这些新的拟南芥凝集素对A-549细胞株显示出弱的细胞毒性，而先前从同一株中分离的拟南芥凝集素B（5）和拟南芥凝集素（6）分别诱导HL-60细胞凋亡或使细胞周期阻滞于G（2）/M期。结果表明，咪唑环上不同的取代基显著地影响了紫花地丁生物碱的细胞毒性。The Journal of Antibiotics（2010）63，165 - 170; doi：10.1038/ja.2010.11; 2010年2月26日在线发表
Four new alkaloids, including two new meleagrin analogs, meleagrin D (1) and E (2), and two new diketopiperazines, roquefortine H (3) and I(4), were isolated from a deep ocean sediment-derived fungus Penicillium sp. Meleagrin D (1) and E (2) possess unprecedented acetate mevalonate-derived side chains on the imidazole moiety. These new meleagrins showed weak cytotoxicity against the A-549 cell line, whereas meleagrin B (5) and meleagrin (6), which were isolated previously from the same strain, induced HL-60 cell apoptosis or arrested the cell cycle through G(2)/M phase, respectively. The results indicate that the distinct substitutions on the imidazole ring significantly influence the cytotoxicity of the meleagrin alkaloids. The Journal of Antibiotics (2010) 63, 165-170; doi:10.1038/ja.2010.11; published online 26 February 2010