Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation
Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation
复制标题
日粮中添加姜黄素可提高宫内生长迟缓仔猪模型的抗氧化能力，上调肝脏中 Nrf2 和 Hmox1 的水平
DOI：
10.3390/nu11122978
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发表时间：
2019-12-01
期刊：
影响因子：
5.9
通讯作者：
Wang, Tian
中科院分区：
文献类型：
--
作者：
Niu, Yu;He, Jintian;Wang, Tian
姜黄素通过多种机制提高抗氧化能力。胎儿宫内发育迟缓(IUGR)已严重影响人类健康。IUGR总是与氧化应激升高和抗氧化防御不足有关。因此，我们选择IUGR仔猪作为模型，研究IUGR对新生仔猪和断奶仔猪抗氧化能力的影响，并确定在断奶IUGR仔猪中添加姜黄素后这些变化是如何调节的。试验一选用8头正常出生体重(NBW)仔猪和8头IUGR仔猪，研究IUGR对新生仔猪抗氧化能力的影响。试验2选用NBW、NC(姜黄素补充组)、IUGR(姜黄素补充组)、IC(姜黄素补充组)4个试验组32头断奶仔猪。结果表明，IUGR仔猪和断奶仔猪肝脏均表现出氧化损伤，抗氧化酶活性低于NBW仔猪。日粮中添加姜黄素可提高IUGR断奶仔猪的增重、采食量、抗氧化酶活性以及肝脏核因子、类红系2(Nrf2)和血红素加氧酶-1(Hmox1)蛋白的表达。总之，IUGR降低了新生仔猪和断奶仔猪的抗氧化能力。姜黄素能有效促进IUGR断奶仔猪生长，提高肝脏抗氧化能力，上调肝脏Nrf2和Hmox1水平。
Curcumin has improved effects on antioxidant capacity via multiple mechanisms. Intrauterine growth retardation (IUGR) has had adverse influences on human health. IUGR is always associated with elevated oxidative stress and deficiencies in antioxidant defense. Therefore, we chose IUGR piglets as a model to investigate the effects of IUGR on antioxidant capacity of newborn and weaned piglets and determine how these alterations were regulated after supplementation with curcumin in weaned IUGR piglets. In experiment 1, eight normal-birth-weight (NBW) and eight IUGR newborn piglets were selected to determine the effect of IUGR on the antioxidant capacity of neonatal piglets. In experiment 2, thirty-two weaned piglets from four experimental groups: NBW, NC (curcumin supplementation), IUGR, IC (curcumin supplementation) were selected. The results showed that both IUGR newborn and weaned piglets exhibited oxidative damage and lower antioxidant enzymes activities in the liver compared with the NBW piglets. Dietary curcumin supplementation increased body-weight gain, feed intake, activities of antioxidant enzymes, and the expressions of nuclear factor, erythroid 2-like 2 (Nrf2) and heme oxygenase-1 (Hmox1) proteins in the liver of weaned piglets with IUGR. In conclusion, IUGR decreased the antioxidant capacity of newborn and weaned piglets. Curcumin could efficiently improve the growth, increase hepatic antioxidant capacity, and upregulate Nrf2 and Hmox1 levels in the liver of IUGR weaned piglets.