Neutrophil-to-lymphocyte ratio predicts prostatic carcinoma in men undergoing needle biopsy.
Neutrophil-to-lymphocyte ratio predicts prostatic carcinoma in men undergoing needle biopsy.
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DOI：
10.18632/oncotarget.5081
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发表时间：
2015-10-13
期刊：
影响因子：
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通讯作者：
Uemura H
中科院分区：
文献类型：
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作者：
Kawahara T;Fukui S;Sakamaki K;Ito Y;Ito H;Kobayashi N;Izumi K;Yokomizo Y;Miyoshi Y;Makiyama K;Nakaigawa N;Yamanaka T;Yao M;Miyamoto H;Uemura H
中性粒细胞与淋巴细胞比率（NLR）是全身炎症反应的简单标志物，已被证明是某些实体恶性肿瘤（包括前列腺癌）的独立预测因子。在本研究中，我们评估了NLR在接受前列腺穿刺活检以初步诊断前列腺癌的男性中的作用。在我们的研究机构中，共检查了3,011名男性的全血细胞计数和游离/总（F/T）前列腺特异性抗原（PSA）比值。其中，1，207例PSA水平在4 - 10 ng/mL之间，810例随后接受前列腺穿刺活检的患者中有357例被发现患有前列腺腺癌。PSA ≥ 20 ng/mL者的NLR值显著高于PSA < 20 ng/mL者（p < 0.001）。活检阳性的男性NLR也显著高于活检阴性的男性（p < 0.001）。采用AUROC曲线确定的NLR临界点2.40，单独NLR和NLR联合F/T PSA比值（临界点：0.15）的阳性/阴性预测值分别为56.6%/60.8%和80.7%/60.1%。多因素分析显示，F/TPSA比值（HR = 3.13）和NLR（HR = 2.21）是前列腺癌的独立危险因素。因此，NLR在前列腺癌患者中可能升高。因此，NLR，与或不与F/T PSA比值组合，可以作为一种新的生物标志物来预测接受前列腺穿刺活检的男性中的前列腺癌。
Neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammatory response, has been demonstrated as an independent prognosticator for some solid malignancies, including prostate cancer. In the present study, we evaluated the role of NLR in men who underwent prostate needle biopsy for their initial diagnosis of prostatic carcinoma. Both complete blood counts and free/total (F/T) prostate-specific antigen (PSA) ratio were examined in a total of 3,011 men in our institution. Of these, 1,207 had a PSA level between 4 and 10 ng/mL, and 357 of 810 who subsequently underwent prostate needle biopsy were found to have prostatic adenocarcinoma. NLR value was significantly higher in men with PSA of ≥ 20 ng/mL than in those with PSA of < 20 ng/mL (p < 0.001). NLR was also significantly higher in men with positive biopsy than in those with negative biopsy (p < 0.001). Using NLR cut-off point of 2.40 determined by the AUROC curve, positive/negative predictive values of NLR alone and NLR combined with F/T PSA ratio (cut-off: 0.15) were 56.6%/60.8% and 80.7%/60.1%, respectively. Multivariate analysis revealed that not only F/T PSA ratio (HR = 3.13) but also NLR (HR = 2.21) was an independent risk factor for prostate cancer. NLR is thus likely elevated in patients with prostate cancer. Accordingly, NLR, with or without combination with F/T PSA ratio, may function as a new biomarker to predict prostate cancer in men undergoing prostate needle biopsy.