Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome
Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome
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DOI：
10.1016/j.atherosclerosis.2008.09.012
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发表时间：
2009-06-01
期刊：
影响因子：
5.3
通讯作者：
Huh, Kap Bum
中科院分区：
文献类型：
--
作者：
Kim, Hyeon Chang;Kim, Dae Jung;Huh, Kap Bum
目的：关于非酒精性脂肪性肝病 (NAFLD) 与动脉粥样硬化之间的关联是否独立于其他代谢性疾病，尚存在争议。我们根据代谢综合征 (MetS) 的存在情况，检查了 NAFLD 与颈动脉内膜中层厚度 (IMT) 之间的关联。方法：对年龄 30-79 岁的 556 名男性和 465 名女性进行横断面分析。通过超声检查评估 NAFLD 的存在。颈动脉 IMT 通过超声检查每条颈总动脉最大 IMT 的平均值来确定。在调整年龄、性别、腰围、收缩压、空腹血糖、总胆固醇/HDL-胆固醇比率、吸烟和饮酒后，使用多元线性和逻辑回归模型评估 NAFLD 和 IMT 之间的独立关联。结果：在调整主要危险因素后，NAFLD 受试者的颈动脉 IMT 高于非 NAFLD 受试者（差异 0.034 mm，p = 0.016）。然而，IMT 差异仅在患有 MetS 的受试者中显着（0.060 mm，p = 0.015），而在没有 MetS 的受试者中不显着（0.015 mm，p = 0.384）。同样，NAFLD 相关 IMT 增加的调整后比值比（定义为性别特异性前五分位数）在所有受试者中为 1.63（95% CI，1.10-2.42），在有 MetS 的受试者中为 2.08（95% CI，1.19-3.66），但在没有 MetS 的受试者中为 1.18（95% CI，0.64-2.19）。当根据代谢异常的数量进行分析时，仅在具有四种或更多异常的受试者中观察到NAFLD-IMT关联。结论：这些结果表明，NAFLD仅在具有多种代谢异常的人群中与颈动脉粥样硬化独立相关。 (C) 2008 Elsevier Ireland Ltd. 保留所有权利。
Objective: Controversy exists as to whether the association between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis is independent of other metabolic disorders. We examined the association between NAFLD and carotid intima-media thickness (IMT) according to the presence of metabolic syndrome (MetS).Methods: A cross-sectional analysis was performed among 556 men and 465 women, ages 30-79 years. The presence of NAFLD was evaluated ultrasonographically. Carotid IMT was determined ultrasonographically by the average of the maximal IMT at each common carotid artery. Independent associations between NAFLD and IMT were assessed using multiple linear and logistic regression models, after adjusting for age, sex, waist circumference, systolic blood pressure, fasting glucose, total/HDL-cholesterol ratio, smoking, and alcohol consumption.Results: After adjusting for major risk factors, subjects with NAFLD had greater carotid IMT than subjects without NAFLD (difference 0.034 mm, p = 0.016). However, the difference in IMT was significant only in subjects with MetS (0.060 mm, p = 0.015) and not in subjects without MetS (0.015 mm,p = 0.384). Similarly, the NAFLD-associated adjusted odds ratio for increased IMT, defined as the sex-specific top quintile, was 1.63 (95% CI, 1.10-2.42) in all subjects and 2.08 (95% CI, 1.19-3.66) in subjects with MetS, but 1.18 (95% CI, 0.64-2.19) in subjects without MetS. When the analysis was performed according to the number of metabolic abnormalities, the NAFLD-IMT association was observed only in subjects with four or more abnormalities.Conclusion: These results suggest that NAFLD is independently associated with carotid atherosclerosis only in people who have multiple metabolic abnormalities. (C) 2008 Elsevier Ireland Ltd. All rights reserved.