THE CHARACTERIZATION OF THE ACTH PRODUCED BY A PRIMARY PITUITARY TUMOUR IN A PATIENT WITH CUSHING'S DISEASE
THE CHARACTERIZATION OF THE ACTH PRODUCED BY A PRIMARY PITUITARY TUMOUR IN A PATIENT WITH CUSHING'S DISEASE
复制标题
库欣病患者原发性垂体肿瘤产生的 ACTH 的特征
DOI：
10.1111/j.1365-2265.1976.tb01975.x
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发表时间：
1976
影响因子：
3.2
通讯作者：
P. Anderson
中科院分区：
文献类型：
--
作者：
DOROTHY T. Krienger;Ho;P. Anderson
与库欣病相关的垂体肿瘤中存在的ACTH的性质以前没有被描述过，也没有与电子显微镜外观相关。本报告描述了从与库欣病相关的垂体肿瘤患者获得的肿瘤组织的培养，以及通过生物测定、免疫测定和Sephadex G‐50凝胶过滤对肿瘤和培养基中ACTH含量的表征。电镜研究也进行了。病理诊断为垂体腺瘤伴嗜碱性PAS阳性颗粒。电镜显示肿瘤细胞大小和形状均匀，存在大小和密度不等的分泌颗粒，内质网管状和空泡状排列紊乱。
The nature of ACTH present in pitutary tumours associated with Cushing's disease has not been previously characterized nor correlated with the electron microscopic appearance. The present report describes the culture of tumour tissue obtained from a patient with a pituitary tumour associated with Cushing's disease, and the characterization of the ACTH content of tumour and media by bioassay, immunoassay, and Sephadex G‐50 gel filtration. Electron microscopic studies were also performed. The pathological diagnosis was pituitary adenoma with basophilic PAS‐positive granules. Electron microscopy showed uniformity of size and shape of the tumour cells, the presence of secretory granules of varying size and density, and disorganized tubular and vacuolar arrays of endoplasmic reticulum.