A History of Acute Pancreatitis in Intraductal Papillary Mucinous Neoplasms of the Pancreas Is a Potential Predictive Factor for Malignant Papillary Subtype
A History of Acute Pancreatitis in Intraductal Papillary Mucinous Neoplasms of the Pancreas Is a Potential Predictive Factor for Malignant Papillary Subtype
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DOI：
10.1159/000320696
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发表时间：
2010-01-01
期刊：
影响因子：
3.6
通讯作者：
Tanaka, Masao
中科院分区：
文献类型：
--
作者：
Tsutsumi, Kosuke;Ohtsuka, Takao;Tanaka, Masao
背景/目的：有几个关于急性胰腺炎发生后发现的导管内乳头状粘液性肿瘤(IPMN)的报道。虽然症状的存在被认为是预测恶性IPMN的一个因素，但很少有报告表明急性胰腺炎病史是否可以预测恶性程度。本研究的目的是评估急性胰腺炎病史与包括乳头状亚型在内的IPMN的临床病理特征之间的关系。方法：回顾分析1990~2009年间手术切除的150个IPMN的临床资料。将其分为有或无急性胰腺炎病史的IPMN，比较两组的临床病理特征。结果：150例患者中有19例(13%)有急性胰腺炎病史。其中9人反复发作胰腺炎；然而，重症胰腺炎并不常见。胰炎组主胰管直径明显大于非胰腺炎组(p=0.04)。胰炎组来自IPMN的癌症发生率显著高于非胰腺炎组(p=0.03)。胰腺炎组肠型IPMN的发生率明显高于非胰腺炎组(P<；0.001)。结论：急性胰腺炎合并IPMN可预测恶性肠型肿瘤的发生。版权所有(C)2011 S.Karger AG，巴塞尔和IAP
Background/Aims: There are several reports regarding intraductal papillary mucinous neoplasms (IPMNs) detected after the occurrence of acute pancreatitis. Although the presence of symptoms is regarded as a factor for predicting malignant IPMNs, there have been few reports demonstrating whether a history of acute pancreatitis is a predictor of malignancy. The aim of this study was to evaluate the relationship between a history of acute pancreatitis and clinicopathological features of IPMNs including the papillary subtype. Methods: The data of 150 IPMNs resected between 1990 and 2009 were retrospectively reviewed. They were classified into IPMNs with or without history of acute pancreatitis, and then the clinicopathological features were compared between the 2 groups. Results: Nineteen (13%) of the 150 patients had a history of acute pancreatitis. Nine of them had repeated episodes of pancreatitis; however, severe pancreatitis was uncommon. The diameter of the main pancreatic duct of the pancreatitis group was significantly larger than that of the nonpancreatitis group (p = 0.04). The pancreatitis group had a significantly higher frequency of carcinoma derived from IPMNs than the nonpancreatitis group (p = 0.03). The incidence of intestinal-type IPMNs in the pancreatitis group was significantly higher than that in the nonpancreatitis group (p < 0.001). Conclusion: Acute pancreatitis associated with IPMNs could predict malignant intestinal-type tumor. Copyright (C) 2011 S. Karger AG, Basel and IAP