Association of Hyper-LDL cholesterolemia with increased Risk of Colorectal Adenoma
Association of Hyper-LDL cholesterolemia with increased Risk of Colorectal Adenoma
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DOI：
10.5754/hge12964
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发表时间：
2014-09-01
影响因子：
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通讯作者：
Lim, Jun Uk
中科院分区：
文献类型：
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作者：
Hong, Seong Hun;Cha, Jae Myung;Lim, Jun Uk
背景/目的：以前关于血脂异常和结直肠腺瘤之间的关联的研究显示了相互矛盾的结果，并且由于样本量小、血脂异常的定义不一致或缺乏完整的血脂谱数据而受到限制。本研究的目的是根据国家胆固醇教育计划-成人治疗小组III的定义确定结直肠腺瘤和血脂异常之间的关系。方法学：我们进行了一项回顾性的横断面研究，受试者接受了筛查性结肠镜检查和血脂检查。比较腺瘤组和对照组的血清血脂异常，并进行多变量分析以确定结直肠腺瘤存在的独立预测因子。结果如下：高LDL胆固醇血症患者更常被纳入腺瘤组比对照组（分别为46.7% vs. 32.1%，p=0.023）和高LDL胆固醇血症（OR = 1.954，95%CI =0.981-3.893，p=0.057）显示了正相关的统计学趋势，此外，近端结直肠腺瘤在高LDL胆固醇血症组中比在正常LDL胆固醇血症组中更常见（p=0.026）结论：高LDL胆固醇血症与结直肠腺瘤的存在相关，尤其是在近端结肠。
Background/Aims:-Previous studies on the association;between dyslipidemia and the presence of colorectal adenoma showed conflicting results, and were limited due;to small sample sizes, inconsistent definitions of dyslipidemia, or a lack of data on full lipid profiles. The aim of this study was to determine the association between colorectal adenomas and dyslipidemia according to the definition by the National Cholesterol Education Program-Adult Treatment Panel III. Methodology: We conducted a retrospective, cross-sectional study in subjects who underwent screening colonoscopy and blood tests for full lipid profiles. Serum dyslipidemia profiles were compared between the adenoma group and the control group, and multivariate analysis was performed to identify independent predictors of the presence of colorectal adenomas. Results: Patients with hyper-LDL cholesterolemia were more frequently included in the adenoma group than the control group (46.7% vs. 32.1%, respectively, p=0.023), and hyper-LDL cholesterolemia (OR = 1.954, 95% CI=0.981-3.893, p=0.057) showed a statistical trend for the positive association, with the presence of colorectal adenomas by multivariate analysis Furthermore, proximal colorectal adenomas were more prevalent in the hyper-LDL cholesterolemia group than in the normal LDL cholesterolemia group (p=0.026) Conclusions: Hyper-LDL cholesterolemia was associated with the presence of colorectal adenomas, especially in the proximal colon.