Topographic coding of olfactory quality: odorant-specific patterns of epithelial responsivity in the salamander.
Topographic coding of olfactory quality: odorant-specific patterns of epithelial responsivity in the salamander.
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嗅觉质量的地形编码：蝾螈上皮反应性的气味特异性模式。
DOI：
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发表时间：
1982
影响因子：
2.5
通讯作者：
D. G. Moulton
中科院分区：
文献类型：
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作者：
A. Mackay;P. Shaman;D. G. Moulton
1. 电生理记录对娃娃鱼腹侧嗅上皮，以探讨是否个别气味可以引起独特模式的受体神经元的反应。2. 在每个上皮的30个位置记录了缓慢的上皮瞬时电压Veog（-）。对于每种气味，从30个记录点的Veog（-）振幅中得出地形模式。3. 9种气味剂分别在7只动物中进行了测试，并绘制了每种动物的Veog（-）振幅的地形模式。由于动物之间的形态差异，每个动物的电极位点被分配到六个上皮区域，然后通过方差分析比较响应。4. 我们还观察到了气味特异性区域反应的差异。气味剂可以根据其引起的响应的地形分布的相似性进行分组。我们观察到，没有两种气味引起完全相同的反应模式。这表明具有相似反应的嗅觉受体神经元聚集在上皮的同一区域。5. 在不同的上皮区域之间的反应性的显著差异，无论测试气味，也被注意到。这种观察结果可能是由于受体神经元密度或总体敏感性的区域差异。6. 结论是，九种测试气味引起的受体细胞反应的地形分布的差异，允许这些反应被区分为嗅球的独特信息模式。
1. Electrophysiological recordings were made on the ventral olfactory epithelium of the salamander Ambystoma tigrinum in order to investigate whether individual odorants can elicit unique patterns of receptor neuron responses. 2. Slow transepithelial voltage transients, Veog(-), were recorded from 30 sites on each epithelium. For each odorant a topographic pattern was derived from the Veog(-) amplitudes across the 30 recording sites. 3. Nine odorants were tested, each in seven animals, and topographic patterns of Veog(-) amplitudes were drawn for each animal. Due to the morphological variability among animals, the electrode sites for each animal were assigned to six epithelial regions for which responses were then compared by analysis of variance. 4. Odorant-specific regional differences in responsivity were observed. The odorants can be grouped according to the similarity of the topographic distributions of responses elicited by them. We observed that no two odorants elicited exactly the same response patterns. This suggests that olfactory receptor neurons with similar responses are grouped together in the same region of the epithelium. 5. Dramatic differences in responsivity among the various epithelial regions, irrespective of the test odorant, were also noted. This observation may be due to regional differences in receptor neuron density or overall sensitivity. 6. It is concluded that differences between the topographic distributions of receptor cell responses, elicited by the nine test odorants, permits these responses to be discriminated as unique patterns of information at the olfactory bulb.