Synthesis Antimicrobial and Anticancer Activity of 1-[(arylalkylidene)amino]-3-(4H-1,2,4-triazol-4-yl)thiourea
Synthesis Antimicrobial and Anticancer Activity of 1-[(arylalkylidene)amino]-3-(4H-1,2,4-triazol-4-yl)thiourea
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1-[(芳基亚烷基)氨基]-3-(4H-1,2,4-三唑-4-基)硫脲的合成抗菌和抗癌活性
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
A. Reddy
中科院分区：
文献类型：
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作者：
U. Kulandaivelu;Bhawatha Chawada;Shireesha Boyapati;A. Reddy
合成了芳基烷叉氨基三唑衍生物（3a-3 j），并测试了它们的抗菌和抗癌活性。4种非致病菌[ E. coli（NCIM 2068）、K. pneumoniae（NCIM 2957）、S. aureus（NCIM 2079）、B. subtilis（NCIM 2921）]两种真菌[ C.白色念珠菌、尼日尔]和两种癌细胞系[HBL-100和HT-29]。所有化合物对B有较好的抗菌活性。化合物3 i对枯草芽孢杆菌的抑制作用与环丙沙星相当。光环。同样，所有化合物都抑制了A.化合物3c对C.白色念珠菌在抗癌活性的情况下，没有一种分子表现出比所用标准品（甲氨蝶呤）更好的活性，尽管它们具有亚微摩尔水平的抑制浓度。
Arylalkylidene derivatives of aminotriazoles ( 3a-3j ) were synthesized and tested for their antimicrobial and anticancer activity. Four non-pathogenic bacteria [ E. coli (NCIM 2068), K. pneumoniae (NCIM 2957), S. aureus (NCIM 2079), B. subtilis (NCIM 2921)] two fungi [ C. albicans , A. niger ] and two cancer cell lines [HBL-100 and HT-29] were employed in the study. All the compounds were found to have better antibacterial activity against B. subtilis than Ciprofloxacin (standard) and compound 3i was equivalent to Ciprofloxacin in inhibiting S. aureas . Similarly all the compounds inhibited the growth of A. niger better than Fluconazole and compound 3c was equivalent to Fluconazole (standard) in inhibiting C. albicans . In case of anticancer activity none of the molecule exhibited activity better than the standard used (Methotrexate), though they have inhibitory concentration at submicromolar level.
DOI：
10.1093/jnci/83.11.757
发表时间：
1991-06-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
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作者：
MONKS, A;SCUDIERO, D;BOYD, M
通讯作者：
BOYD, M
DOI：
10.1016/s0065-2571(98)00017-x
发表时间：
1999-01-01
期刊：
ADVANCES IN ENZYME REGULATION, VOL 39
影响因子：
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作者：
Finch, RA;Liu, MC;Sartorelli, AC
通讯作者：
Sartorelli, AC