Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process
Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process
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DOI：
10.1016/j.jneuroim.2009.02.012
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发表时间：
2009-05-29
影响因子：
3.3
通讯作者：
Mora, Gabriele
中科院分区：
文献类型：
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作者：
Mantovani, Stefania;Garbelli, Silvia;Mora, Gabriele
在这项工作中，我们表明，与健康对照相比，散发性肌萎缩侧索硬化症患者的血液中表现出免疫学变化，例如：i）CD 4+细胞水平增加，CD 8 + T淋巴细胞水平降低，后者是由于抗细胞凋亡分子表达减少而导致的。Bcl-2; ii）在疾病较不严重阶段的患者中显著降低的CD 4 + CD 25+调节性T（Treg）细胞和单核细胞（CD 14+）水平，表明它们向原发性神经变性的CNS区域的早期募集; iii）单核细胞中作为活化标志物的HLA-DR表达和CCR 2表达降低。由于常驻小胶质细胞部分来自循环活化单核细胞和Treg细胞是已知的与本地小胶质细胞相互作用，这项研究加强了适应性免疫系统参与ALS的病理生物学与神经炎症过程的假设。(C)2009 Elsevier B. V.保留所有权利。
In this work we show that patients with sporadic amyotrophic lateral sclerosis exhibit immunological alterations in their blood, with respect to healthy controls, such as: i) increased levels of CD4+ cells and decreased levels of CD8+ T lymphocytes, the latter due to the reduced expression of the anti-apoptotic molecule Bcl-2; ii) significantly reduced CD4+CD25+ regulatory T (Treg) cells and monocytes (CD14+) levels in patients at a less severe stage of disease, suggesting their early recruitment towards the CNS area of primary neurodegeneration; iii) reduced expression of HLA-DR and CCR2 expression, as markers of activation, in monocytes. Since resident microglia partially derives from circulating activated monocytes and Treg cells are known to interact with the local microglia, this study strengthens the hypothesis of an involvement of the adaptive immune system associated with a neuroinflammatory process in the pathobiology of ALS. (C) 2009 Elsevier B.V. All rights reserved.