Bioactive silicon nitride: A new therapeutic material for osteoarthropathy.
Bioactive silicon nitride: A new therapeutic material for osteoarthropathy.
复制标题
DOI：
10.1038/srep44848
复制
发表时间：
2017-03-22
影响因子：
4.6
通讯作者：
Bal SB
中科院分区：
文献类型：
--
作者：
Pezzotti G;Marin E;Adachi T;Rondinella A;Boschetto F;Zhu W;Sugano N;Bock RM;McEntire B;Bal SB
虽然生物陶瓷和活细胞之间的相互作用是复杂的，但它主要由植入物的表面化学决定。因此，更深入地了解生物陶瓷与活组织的化学相互作用最终可能导致新的治疗策略。然而，控制这些相互作用的物理和化学原理仍然不清楚。这种生物协同作用的复杂性，探讨在本文中通过检查一个相对较新的生物陶瓷，氮化硅（Si3N4）的特殊表面化学。基于先前的研究，本文旨在获得新的见解Si3N4和活细胞之间的生物相互作用，作为其表面在纳米尺度上的非化学计量化学性质的结果。我们在这里展示了尚未公布的表面化学细节，并根据这些新数据，制定了一个模型，最终，Si3N4如何影响细胞信号转导功能和分化机制。换句话说，我们用化学术语解释它与活细胞的相互作用。这些新发现表明，Si3N4可能为各种骨或关节疾病提供独特的新药物疗法和有效的治疗方法。
While the reciprocity between bioceramics and living cells is complex, it is principally governed by the implant’s surface chemistry. Consequently, a deeper understanding of the chemical interactions of bioceramics with living tissue could ultimately lead to new therapeutic strategies. However, the physical and chemical principles that govern these interactions remain unclear. The intricacies of this biological synergy are explored within this paper by examining the peculiar surface chemistry of a relatively new bioceramic, silicon nitride (Si3N4). Building upon prior research, this paper aims at obtaining new insights into the biological interactions between Si3N4 and living cells, as a consequence of the off-stoichiometric chemical nature of its surface at the nanometer scale. We show here yet unveiled details of surface chemistry and, based on these new data, formulate a model on how, ultimately, Si3N4 influences cellular signal transduction functions and differentiation mechanisms. In other words, we interpret its reciprocity with living cells in chemical terms. These new findings suggest that Si3N4 might provide unique new medicinal therapies and effective remedies for various bone or joint maladies and diseases.