The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction
The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction
复制标题
DOI：
10.1016/j.stemcr.2013.04.003
复制
发表时间：
2013-06-04
影响因子：
5.9
通讯作者：
Gilley, David
中科院分区：
文献类型：
--
作者：
Kannan, Nagarajan;Huda, Nazmul;Gilley, David
端粒对基因组完整性至关重要，但对其在正常人类乳腺中的调节作用知之甚少。我们现在证明，表型定义的细胞群富含腔祖细胞（LPs），其特征是端粒异常短，与供体年龄无关。此外，我们发现多种DNA损伤反应蛋白与端粒共定位在bbbb95 %的LPs中，但在
Telomeres are essential for genomic integrity, but little is known about their regulation in the normal human mammary gland. We now demonstrate that a phenotypically defined cell population enriched in luminal progenitors (LPs) is characterized by unusually short telomeres independently of donor age. Furthermore, we find that multiple DNA damage response proteins colocalize with telomeres in >95% of LPs but in