Cargo recognition and degradation by selective autophagy.
Cargo recognition and degradation by selective autophagy.
复制标题
通过选择性自噬的货物识别和降解。
DOI:
10.1038/s41556-018-0037-z
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发表时间:
2018-03
影响因子:
21.3
通讯作者:
Klionsky DJ
中科院分区:
文献类型:
--
作者:
Gatica D;Lahiri V;Klionsky DJ
Macroautophagy, initially described as a non-selective nutrient recycling process, is essential for the removal of multiple cellular components. In the past three decades, selective autophagy has been characterized as a highly regulated and specific degradation pathway for removal of unwanted cytosolic components and damaged and/or superfluous organelles. Here, we discuss different types of selective autophagy, emphasizing the role of ligand receptors and scaffold proteins in providing cargo specificity, and highlight unanswered questions in the field.
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DOI:
10.1073/pnas.1404171111
发表时间:
2014-09-30
影响因子:
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