Bubble-based acoustic radiation force using chirp insonation to reduce standing wave effects
Bubble-based acoustic radiation force using chirp insonation to reduce standing wave effects
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DOI：
10.1016/j.ultrasmedbio.2006.07.039
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发表时间：
2007-02-01
影响因子：
2.9
通讯作者：
O'Donnell, Matthew
中科院分区：
文献类型：
--
作者：
Erpelding, Todd N.;Hollman, Kyle W.;O'Donnell, Matthew
基于气泡的声辐射力可以测量组织的局部粘弹性特性。应用于激光生成的气泡的高强度声波诱导与当地杨的模量成反比的位移。在某些情况下，长脉冲持续时间是可取的，但容易受到直立伪像的影响，这些脉冲损坏了位移测量。研究了Chirp脉冲声音辐射力，作为减少驻波伪影的一种方法。线性频率扫描幅度为100、200和300 kHz的CHIRP脉冲将其二重为1.5 MHz约1.5 MHz施加到明胶幻像内的玻璃珠，并在猪镜片内使用激光生成的气泡。将超声传感器轴向转换为不同的驻波条件，同时使用CHIRP脉冲和1.5 MHz张力脉冲脉冲进行比较的持续时间和峰值稀有压力。结果表明，使用CHIRP脉冲显着降低了驻波效应，其位移与声强度和气泡大小成正比。
Bubble-based acoustic radiation force can measure local viscoelastic properties of tissue. High intensity acoustic waves applied to laser-generated bubbles induce displacements inversely proportional to local Young's modulus. In certain instances, long pulse durations are desirable but are susceptible to standing wave artifacts, which corrupt displacement measurements. Chirp pulse acoustic radiation force was investigated as a method to reduce standing wave artifacts. Chirp pulses with linear frequency sweep magnitudes of 100, 200 and 300 kHz centered around 1.5 MHz were applied to glass beads within gelatin phantoms and laser-generated bubbles within porcine lenses. The ultrasound transducer was translated axially to vary standing wave conditions, while comparing displacements using chirp pulses and 1.5 MHz tone burst pulses of the same duration and peak rarefactional pressure. Results demonstrated significant reduction in standing wave effects using chirp pulses, with displacement proportional to acoustic intensity and bubble size.