Bmc Complementary and Alternative Medicine Ginger Extract Inhibits Lps Induced Macrophage Activation and Function
Bmc Complementary and Alternative Medicine Ginger Extract Inhibits Lps Induced Macrophage Activation and Function
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发表时间：
2008
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通讯作者：
S. Tripathi;D. Bruch;D. Kittur;S. Edu ; Dilip;Kittur
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作者：
S. Tripathi;D. Bruch;D. Kittur;S. Edu ; Dilip;Kittur
背景：巨噬细胞在宿主防御中发挥双重作用。它们通过对抗原暴露产生炎症反应而充当第一道防线，并且还充当抗原呈递细胞并启动适应性免疫应答。它们也是炎症部位的主要浸润细胞。抑制巨噬细胞活化是调节炎症的可能方法之一。在这方面，正在研究传统办法和替代办法。生姜是一种具有广泛抗炎作用的草药产品，被用作一些炎症性疾病（如风湿性疾病）的替代药物。在本研究中，我们研究了生姜提取物对巨噬细胞活化的LPS刺激的存在下的效果。
Background: Macrophages play a dual role in host defence. They act as the first line of defence by mounting an inflammatory response to antigen exposure and also act as antigen presenting cells and initiate the adaptive immune response. They are also the primary infiltrating cells at the site of inflammation. Inhibition of macrophage activation is one of the possible approaches towards modulating inflammation. Both conventional and alternative approaches are being studied in this regard. Ginger, an herbal product with broad anti inflammatory actions, is used as an alternative medicine in a number of inflammatory conditions like rheumatic disorders. In the present study we examined the effect of ginger extract on macrophage activation in the presence of LPS stimulation.