Cellular radiation effects and the bystander response
Cellular radiation effects and the bystander response
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DOI：
10.1016/j.mrfmmm.2005.12.001
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发表时间：
2006-05-11
影响因子：
2.3
通讯作者：
Little, John B.
中科院分区：
文献类型：
--
作者：
Little, John B.
这份报告简要回顾了过去两年中报道的一些发现，这些发现增强了我们对辐射诱导的旁观者效应的理解。这些进展包括：技术进步；氧化应激的作用；细胞质辐射的影响；细胞间通讯；连接蛋白43介导的细胞间通讯由辐射诱导的证据。文中还讨论了几个悬而未决的问题。这些包括：从受辐射的细胞向旁观者细胞传递的信号(S)是什么；旁观者反应与辐射的其他非靶向效应之间有什么关系；旁观者反应是否有有益的影响；旁观者效应对辐射防护有什么意义？(C)2005 Elsevier B.V.保留所有权利。
This report reviews briefly some of the findings reported over the past 2 years that enhance our understanding of the radiation-induced bystander effect. These developments include: technicological advances; the role of oxidative stress; the effect of cytoplasmic irradiation; cell-to-cell communication; and evidence that Connexin 43 mediated intercellular communication is induced by radiation exposure. A few overriding unanswered questions are discussed. These include: what is the signal(s) transmitted from irradiated to bystander cells; what is the relationship between the bystander response and other non-targeted effects of radiation; are there beneficial effects associated with the bystander response; and what is the significance of the bystander effect for radiation protection? (c) 2005 Elsevier B.V. All rights reserved.