Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene
Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene
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DOI：
10.1038/sj.gene.6364221
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发表时间：
2005-08-01
影响因子：
5
通讯作者：
Schumann, RR
中科院分区：
文献类型：
--
作者：
Schröder, NWJ;Meister, D;Schumann, RR
牙周炎是一种影响牙齿周围结缔组织的炎症性疾病，会导致牙齿脱落。与牙周炎相关的病原体与toll样受体（TLRs）相互作用，诱导细胞因子引起和加重疾病。我们筛选了197名患有广泛性牙周炎的患者，检测TLR-4的Asp299Gly和Thr399Ile以及TLR-2的Arg753Gln的存在，并与匹配的对照组进行比较。TLR-4的单核苷酸多态性（SNPs）在患者中升高(奇数比3.650,95% CI 1.573-8.467， P
Periodontitis is an inflammatory disease affecting the connective tissue surrounding the teeth leading to tooth loss. Pathogens associated with periodontitis interact with Toll-like receptors ( TLRs) to induce cytokines causing and aggravating disease. We screened 197 individuals suffering from generalized periodontitis for the presence of Asp299Gly and Thr399Ile of TLR-4 as well as Arg753Gln of TLR-2 in comparison to matched controls. Single-nucleotide polymorphisms ( SNPs) of TLR-4 were elevated among patients ( odd's ratio 3.650, 95% CI 1.573-8.467, P