INVITRO INTERACTIONS OF THE AROMATIC RETINOIDS RO-10-9359 (ETRETINATE) AND RO-10-1670 (ACITRETIN), ITS MAIN METABOLITE, WITH HUMAN SERUM-LIPOPROTEINS AND ALBUMIN
INVITRO INTERACTIONS OF THE AROMATIC RETINOIDS RO-10-9359 (ETRETINATE) AND RO-10-1670 (ACITRETIN), ITS MAIN METABOLITE, WITH HUMAN SERUM-LIPOPROTEINS AND ALBUMIN
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DOI：
10.1016/0167-4889(90)90108-p
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发表时间：
1990-11-12
期刊：
影响因子：
--
通讯作者：
DUBERTRET, L
中科院分区：
文献类型：
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作者：
CARILLET, V;MORLIERE, P;DUBERTRET, L
血清脂蛋白是芳香族类维生素A Ro 10-9359（阿维A酯）的良好载体，也是其在人体内的主要代谢物Ro 10-670（阿维A）的良好载体。多达约200和130个阿维A酯分子以及200和70个阿曲汀分子可分别结合一种LDL和一种HDL。相比之下，人血清白蛋白仅结合约 10 个阿维A酯或 30 个阿维A分子。在载有类维生素A的完整人血清中，脂蛋白携带大约。总阿维A酯的67%或约。占阿维A总量的37%。在阿维A酯的具体情况中，低密度脂蛋白占脂蛋白携带的阿维A酯的约30%。
Serum lipoproteins are good carriers for aromatic retinoid Ro 10-9359 (etretinate) and to a lesser extent for its main metabolite in human Ro 10-670 (acitretin). Up to about 200 and 130 etretinate molecules and 200 and 70 acitretin molecules can bind to one LDL and one HDL, respectively. In contrast human serum albumin only binds about 10 etretinate or 30 acitretin molecules. In whole human serum loaded with the retinoids, lipoproteins carry approx. 67% of total etretinate or approx. 37% of total acitretin. In the particular case of etretinate, low density lipoproteins account for about 30% of the lipoprotein-carried etretinate.