Prospective Study on Occupational Stress and Risk of Stroke
Prospective Study on Occupational Stress and Risk of Stroke
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DOI：
10.1001/archinternmed.2008.503
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发表时间：
2009-01-12
影响因子：
--
通讯作者：
Ishikawa, Shizukiyo
中科院分区：
文献类型：
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作者：
Tsutsumi, Akizumi;Kayaba, Kazunori;Ishikawa, Shizukiyo
背景资料：没有前瞻性研究探讨职业压力之间的关联，根据工作需求控制模型和中风的风险在亚洲population.Methods：我们进行了一项多中心的社区为基础的前瞻性研究，6553日本男性和女性工人。职业压力进行了评估，使用日文版的工作需求控制模型问卷。我们使用考克斯比例风险模型来评估职业紧张和strok.Results之间的关联：在平均随访11年，我们确定了147事件中风。多变量分析显示，工作紧张的男性总中风风险增加2倍以上（高工作要求和低工作控制的结合）（风险比，2.73; 95%置信区间，1.17-6.38）与低应变的对应男性相比（低工作要求和高工作控制的组合）调整年龄，教育程度，职业，吸烟状况，饮酒，体育活动和研究领域后。对生物学风险因素的额外调整降低了风险比，但仍有统计学意义（风险比，2.53; 95%置信区间，1.08-5.94）。在女性中，没有统计学上的显着差异，发现任何中风发病率之间的工作特征categorization.Conclusion：职业紧张与工作紧张与中风事件在日本男性。
Background: No prospective studies have examined the association between occupational stress according to the job demand-control model and the risk of stroke in Asian populations.Methods: We conducted a multicenter community-based prospective study of 6553 Japanese male and female workers. Occupational stress was evaluated using a Japanese version of the job demand-control model questionnaire. We used the Cox proportional hazards model to evaluate the association between occupational stress and stroke.Results: During a mean follow-up of 11 years, we identified 147 incident strokes. Multivariable analysis revealed a more than 2-fold increase in the risk of total stroke among men with job strain (combination of high job demand and low job control) (hazard ratio, 2.73; 95% confidence interval, 1.17-6.38) compared with counterpart men with low strain (combination of low job demand and high job control) after adjustment for age, educational attainment, occupation, smoking status, alcohol consumption, physical activity, and study area. Additional adjustments for biologic risk factors attenuated the hazard ratio, but there continued to be statistical significance (hazard ratio, 2.53; 95% confidence interval, 1.08-5.94). In women, no statistically significant differences were found for any stroke incidence among the job characteristic categories.Conclusion: Occupational stress related to job strain was associated with incident strokes among Japanese men.