Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation.
Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation.
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DOI：
10.1667/rr14530.1
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发表时间：
2016-12
影响因子：
3.4
通讯作者：
O'Banion MK
中科院分区：
文献类型：
--
作者：
Sweet TB;Hurley SD;Wu MD;Olschowka JA;Williams JP;O'Banion MK
在评估与我们环境中的自然和人为来源有关的潜在健康风险时，了解辐射的剂量毒性特征至关重要。本研究的目的是评估低剂量全身高能带电（HZE）铁（Fe）离子和低能量γ暴露对海马齿状回内成年出生的神经元增殖和分化的影响，这些细胞被认为在记忆调节中起着关键作用。为了确定脑对全身Fe离子与γ辐射暴露的剂量反应特征，用1 GeV/n Fe离子或静态137 Cs源（0.662 MeV）以0至300 cGy的剂量范围照射C57 BL/6 J小鼠。在照射后48 h和1个月观察神经发生情况。这些实验表明，全身暴露于Fe离子或γ辐射导致：1。海马齿状回内细胞分裂的急性减少，分别在低至30和100 cGy的Fe离子和γ辐射剂量下检测到;和2。辐射后一个月，新分化的神经元（DCX免疫反应性）减少，在低至100 cGy的剂量下检测到Fe离子和γ射线的显著减少。这里提供的数据有助于我们了解大脑对全身铁离子和伽马射线的反应，并可能有助于为医疗或放射/核事件期间或长时间太空旅行期间与全身暴露相关的健康风险评估提供信息。
Understanding the dose-toxicity profile of radiation is critical when evaluating potential health risks associated with natural and man-made sources in our environment. The purpose of this study was to evaluate the effects of low-dose whole-body high-energy charged (HZE) iron (Fe) ions and low-energy gamma exposure on proliferation and differentiation of adult-born neurons within the dentate gyrus of the hippocampus, cells deemed to play a critical role in memory regulation. To determine the dose-response characteristics of the brain to whole-body Fe-ion vs. gamma-radiation exposure, C57BL/6J mice were irradiated with 1 GeV/n Fe ions or a static 137Cs source (0.662 MeV) at doses ranging from 0 to 300 cGy. The neurogenesis was analyzed at 48 h and one month postirradiation. These experiments revealed that whole-body exposure to either Fe ions or gamma radiation leads to: 1. An acute decrease in cell division within the dentate gyrus of the hippocampus, detected at doses as low as 30 and 100 cGy for Fe ions and gamma radiation, respectively; and 2. A reduction in newly differentiated neurons (DCX immunoreactivity) at one month postirradiation, with significant decreases detected at doses as low as 100 cGy for both Fe ions and gamma rays. The data presented here contribute to our understanding of brain responses to whole-body Fe ions and gamma rays and may help inform health-risk evaluations related to systemic exposure during a medical or radiologic/nuclear event or as a result of prolonged space travel.