Prostate motion during radiotherapy of prostate cancer patients with and without application of a hydrogel spacer: a comparative study
Prostate motion during radiotherapy of prostate cancer patients with and without application of a hydrogel spacer: a comparative study
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DOI：
10.1186/s13014-015-0526-1
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发表时间：
2015-10-24
影响因子：
3.6
通讯作者：
Eade, Thomas
中科院分区：
文献类型：
--
作者：
Juneja, Prabhjot;Kneebone, Andrew;Eade, Thomas
背景和目的：在前列腺放疗期间，使用组织扩张器（水凝胶）来保护直肠免受增加的辐射正变得越来越流行。本研究的目的是探讨放射治疗过程中的intrafraction前列腺运动的影响的组织扩张器（水凝胶）。方法和材料：真实的时间前列腺运动进行了分析，为26例患者和742个分数; 12例患者和14例患者没有水凝胶（SpaceOAR T）。结果：在治疗过程中，使用和不使用水凝胶的患者的平均运动的平均值（+/-标准差）分别为1.5（+/- 0.8 mm）和1.1（+/- 0.9 mm）（p < 0.05）。使用和不使用水凝胶的患者的平均运动时间>3 mm分别为7.7%（+/-1.1%）和4.5%（+/-0.9%）（p > 0.05）。凝胶年龄、分割次数和治疗时间对前列腺运动没有影响（R-2 < 0.05）。结论：使用凝胶和不使用凝胶的患者在分割内运动的差异在测量不确定度范围内（< 1 mm）。这一结果证实，如果有临床指征，添加垫片并不能消除对分次内运动管理的需求。
Background and purpose: The use of a tissue expander (hydrogel) for sparing of the rectum from increased irradiation during prostate radiotherapy is becoming popular. The goal of this study is to investigate the effect of a tissue expander (hydrogel) on the intrafraction prostate motion during radiotherapy.Methods and material: Real time prostate motion was analysed for 26 patients and 742 fractions; 12 patients with and 14 patients without hydrogel (SpaceOAR T). The intra-fraction motion was quantified and compared between the two groups.Results: The average (+/- standard deviation) of the mean motion during the treatment for patients with and without hydrogel was 1.5 (+/- 0.8 mm) and 1.1 (+/- 0.9 mm) respectively (p < 0.05). The average time of motion >3 mm for patients with and without hydrogel was 7.7 % (+/- 1.1 %) and 4.5 % (+/- 0.9 %) respectively (p > 0.05). The hydrogel age, fraction number and treatment time were found to have no effect (R-2 < 0.05) on the prostate motion.Conclusions: Differences in intrafraction motion in patients with hydrogel and without hydrogel were within measurement uncertainty (< 1 mm). This result confirms that the addition of a spacer does not negate the need for intrafraction motion management if clinically indicated.