Amplitude-based optimal respiratory gating in positron emission tomography in patients with primary lung cancer
Amplitude-based optimal respiratory gating in positron emission tomography in patients with primary lung cancer
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DOI：
10.1007/s00330-014-3362-z
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发表时间：
2014-12-01
影响因子：
5.9
通讯作者：
Visser, Eric P.
中科院分区：
文献类型：
--
作者：
Grootjans, Willem;de Geus-Oei, Lioe-Fee;Visser, Eric P.
PET成像过程中的呼吸运动引入了定量和诊断的不准确性，这可能导致非最佳的患者处理。采用基于幅度的最优呼吸门控(ORG)算法，研究呼吸门控对图像量化的影响。对66例肺癌患者进行全身FDG-PET/CT检查。呼吸信号是使用集成在患者胸部周围的弹性腰带中的压力传感器获得的。用50%、35%和20%的采集PET数据(占空比)重建组织图像。病变按解剖位置分组。计算ORG和非门控图像之间病变体积的差异和平均FDG摄取(SUV Mean)，中叶和下叶病变在所有占空比下SUV平均值显著增加，而在占空比为35%和20%时体积显著减少。在20%的占空比下，可观察到上叶病变的SUV平均值显著增加，体积显著减小。在所有占空比中，中心性病变的SUV平均值显著增加，而在占空比为20%的情况下观察到显著的体积减小。这项研究表明，在反应监测和放射治疗计划方面，ORG可以影响临床PET成像。欧分量化病变体积和PET摄取对于患者处理非常重要。欧分呼吸运动伪影在PET图像量化中引入不准确的欧分呼吸运动伪影通过选择占空周期来维持图像质量欧洲分心呼吸门控对病变量化的影响取决于解剖位置。
Respiratory motion during PET imaging introduces quantitative and diagnostic inaccuracies, which may result in non-optimal patient management. This study investigated the effects of respiratory gating on image quantification using an amplitude-based optimal respiratory gating (ORG) algorithm.Whole body FDG-PET/CT was performed in 66 lung cancer patients. The respiratory signal was obtained using a pressure sensor integrated in an elastic belt placed around the patient's thorax. ORG images were reconstructed with 50 %, 35 %, and 20 % of acquired PET data (duty cycle). Lesions were grouped into anatomical locations. Differences in lesion volume between ORG and non-gated images, and mean FDG-uptake (SUVmean) were calculated.Lesions in the middle and lower lobes demonstrated a significant SUVmean increase for all duty cycles and volume decrease for duty cycles of 35 % and 20 %. Significant increase in SUVmean and decrease in volume for lesions in the upper lobes were observed for a 20 % duty cycle. The SUVmean increase for central lesions was significant for all duty cycles, whereas a significant volume decrease was observed for a duty cycle of 20 %.This study implies that ORG could influence clinical PET imaging with respect to response monitoring and radiotherapy planning.aEuro cent Quantifying lesion volume and uptake in PET is important for patient managementaEuro cent Respiratory motion artefacts introduce inaccuracies in quantification of PET imagesaEuro cent Amplitude-based optimal respiratory gating maintains image quality through selection of duty cycleaEuro cent The effect of respiratory gating on lesion quantification depends on anatomical location.