Central alpha 2-adrenoceptor responsiveness in borderline hypertensive rats.
Central alpha 2-adrenoceptor responsiveness in borderline hypertensive rats.
复制标题
临界高血压大鼠的中枢α2-肾上腺素受体反应性。
DOI：
10.1097/00004872-199106000-00010
复制
发表时间：
1991
影响因子：
4.9
通讯作者：
Jones,SY
中科院分区：
文献类型：
--
作者：
DiBona,GF;Jones,SY
增加饮食NaCl摄入增加中枢神经系统α 2-肾上腺素受体的反应性，其调节自发性高血压大鼠（SHR）而不是Wistar-Kyoto（WKY）正常血压大鼠的肾功能的神经控制。临界性高血压大鼠（BHR）是SHR和WKY的第一代子代。随着饮食NaCl摄入量的增加，BHR发展为高血压，并表达高血压SHR父母的其他特征。本研究旨在确定BHR中饮食NaCl摄入量增加是否会增强中枢神经系统[α] 2-肾上腺素受体的反应性。在BHR中增加饮食氯化钠摄入量（8%与1%氯化钠）六周，增强了脑室内给予分级剂量（5、25和125 [微] g）[alpha] 2肾上腺素受体激动剂胍那苄的降压、心动过缓、肾交感神经抑制和利尿反应。结果表明，中枢神经系统[α] 2-肾上腺素受体的反应性增加的潜力是遗传传递给BHR的SHR，并可能暴露在BHR增加饮食氯化钠摄入量。
Increased dietary NaCI intake increases the responsiveness of central nervous system oc2-adrenoceptors which regulate the neural control of renal function in spontaneously hypertensive rats (SHR) but not Wistar-Kyoto (WKY) normotensive rats. The borderline hypertensive rat (BHR) is the first filial offspring of the SHR and the WKY. With increased dietary NaCI intake, the BHR develops hypertension and expresses other characteristics of the hypertensive SHR parent. This investigation sought to determine whether increased dietary NaCI intake in the BHR enhances the responsiveness of central nervous system [alpha] 2-adrenoceptors. Six weeks of increased dietary NaCI intake (8% versus 1% NaCI) in BHR augmented the depressor, bradycardic, renal sympatho-inhibitory and diuretic responses to intracerebroventricular administration of graded doses (5, 25 and 125 [micro] g) of the [alpha] 2-adrenoceptor agonist, guanabenz. The results suggest that the potential for an increased responsiveness of central nervous system [alpha] 2-adrenoceptors is genetically transmitted to the BHR by the SHR and may be exposed in the BHR by increased dietary NaCI intake.