Estrogen-independent ovary formation in the medaka fish, Oryzias latipes
Estrogen-independent ovary formation in the medaka fish, Oryzias latipes
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DOI：
10.2108/zsj.17.65
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发表时间：
2000-01-01
影响因子：
0.9
通讯作者：
Yamashita, I
中科院分区：
文献类型：
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作者：
Kawahara, T;Yamashita, I
为了研究雌性类固醇激素雌激素是否是青鳉鱼雌性性腺性别决定（或卵巢形成）的天然诱导物，研究了芳香化酶抑制剂和抗雌激素对性腺性别分化的影响。我们发现，这两种药物在两性中对遗传决定的性别分化没有表现出任何明显的影响。然而，芳香化酶抑制剂削弱了雄激素（一种雄性类固醇）的矛盾作用，而抗雌激素则抑制了雌激素引起的雄性到雌性的性逆转。用雄激素处理受精卵后，两性的性腺发育都受到干扰，表明性类固醇的合成对青鳉胚胎的性腺发育是有害的。这些结果是一致的，与以前的观察，性类固醇激素的性腺性别分化的发病前不合成，并建议在遗传雌性青鳉鱼卵巢的形成是不依赖于雌激素。
To investigate whether a female sex steroid, estrogen, acts as a natural inducer of female gonadal sex determination (or ovary formation) in the medaka fish, Oryzias latipes, the effects of an aromatase inhibitor and anti-estrogens on sexual differentiation of gonads were examined. We found that both drugs did not show any discernible effects on the genetically determined sex differentiation in both sexes. However, the aromatase inhibitor impaired the paradoxical effects of androgen (a male sex steroid), and the antiestrogens inhibited the male-to-female sex reversal caused by estrogen. Treatments of the fertilized eggs with androgen disturbed the gonadal sex developments in both sexes, suggesting that sex steroid synthesis is detrimental to the gonadal sex developments in the medaka embryos. These results are consistent with the previous observation that sex steroids are not synthesized before the onset of gonadal sex differentiation, and suggest that ovary formation in the genetic females of the medaka fish is not dependent on estrogen.