The Potential of Metabolic Imaging.
The Potential of Metabolic Imaging.
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DOI：
10.1053/j.semnuclmed.2015.09.004
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发表时间：
2016-01
影响因子：
4.9
通讯作者：
Keshari KR
中科院分区：
文献类型：
--
作者：
Di Gialleonardo V;Wilson DM;Keshari KR
代谢成像是分子成像的一个领域，专注于代谢途径的变化，以评估不同的临床状况。非侵入性地靶向和量化代谢变化是促进诊断和评估治疗反应的有效方法。本综述仅涉及针对代谢途径的技术。其他分子成像策略，例如亲和力/受体成像或微环境依赖性方法超出了本综述的范围。在这里，我们描述了临床可转化代谢成像模式的当前技术水平。具体来说，我们将重点关注正电子发射断层扫描 (PET) 和磁共振波谱 (MRS)，包括热平衡下的传统 1H 和 13C MRS 以及超极化磁共振成像 (HP MRI)。在本文中，我们首先概述了在许多病理条件下改变的代谢途径以及用于研究这些改变的相应探针和技术。然后，我们将描述代谢成像在几种常见疾病中的应用，包括癌症、神经退行性疾病、心肌缺血和感染/炎症。
Metabolic imaging is a field of molecular imaging that focuses and targets changes in metabolic pathways for the evaluation of different clinical conditions. Targeting and quantifying metabolic changes non-invasively is a powerful approach to facilitate diagnosis and evaluate therapeutic response. This review addresses only techniques targeting metabolic pathways. Other molecular imaging strategies, such as affinity/receptor imaging or microenvironment-dependent methods are beyond the scope of this review. Here we describe the current state of the art in clinically translatable metabolic imaging modalities. Specifically, we will focus on positron emission tomography (PET) and magnetic resonance spectroscopy (MRS), including conventional 1H and 13C MRS at thermal equilibrium and hyperpolarized magnetic resonance imaging (HP MRI). In this paper, we first provide an overview of metabolic pathways that are altered in many pathological conditions and the corresponding probes and techniques used to study those alterations. We will then describe the application of metabolic imaging to several common diseases including cancer, neurodegeneration, cardiac ischemia, and infection/inflammation.