Anticholinergic effect on cognition (AEC) of drugs commonly used in older people
Anticholinergic effect on cognition (AEC) of drugs commonly used in older people
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DOI：
10.1002/gps.4507
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发表时间：
2017-06-01
影响因子：
4
通讯作者：
Taylor, David M.
中科院分区：
文献类型：
--
作者：
Bishara, Delia;Harwood, Daniel;Taylor, David M.
目的：老年人使用抗胆碱能药物会增加认知功能减退、痴呆和死亡的风险。方法：我们确定了在老年人中广泛使用的药物，并尝试根据我们的三分量表对其进行分类，根据体外抗胆碱能效力、跨越血脑屏障的能力和标准文本中的陈述对AEC进行评分。结果：总共检查了165种药物。我们鉴定出21种药物的AEC评分为3，18种药物的AEC评分为2，21种药物的AEC评分为1，62种药物的AEC评分为0。由于资料不足，我们无法对43种药物进行分类。结论：大量老年人常用药物可能与认知障碍有关。版权所有(C)2016 John Wiley&Sons，Ltd.
Objective: Use of anticholinergic drugs in older people is associated with increased risk of cognitive decline and of dementia and death.Method: We identified drugs widely used in older people and attempted to classify their anticholinergic effect on cognition (AEC) according to our three-point scale which scored AEC according to in vitro anticholinergic potency, capacity to cross the blood-brain barrier and statements made in standard texts.Results: In total, 165 drugs were examined. We identified 21 drugs with an AEC score of 3, 18 with a score of 2, 21 with a score of 1 and 62 with a score of 0. Owing to insufficient information, we were unable to classify 43 drugs.Conclusions: A large number of drugs commonly used in older people are likely to be associated with cognitive impairment. Copyright (C) 2016 John Wiley & Sons, Ltd.