Transforming growth factor-beta 1-deficient mice: Identification of isoform-specific activities in vivo
Transforming growth factor-beta 1-deficient mice: Identification of isoform-specific activities in vivo
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DOI：
10.1002/jlb.59.6.769
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发表时间：
1996-06-01
影响因子：
5.5
通讯作者：
Roberts, AB
中科院分区：
文献类型：
--
作者：
Letterio, JJ;Roberts, AB
一个显着的活动范围已被归因于称为转化生长因子-β（TGF-β）的蛋白质家族。每种都在发育和体内平衡中发挥重要作用，影响间充质-上皮相互作用，调节细胞分化并维持对细胞增殖的控制，尽管体外活性比较表明高度的功能相似性，最近对TGF-β 1基因靶向缺失的小鼠的研究表明，真正的同种型-体内确实存在特异性活性，并且这三种哺乳动物同种型在功能上不是冗余的。这种方法已经确定了TGF-β 1在建立和维持正常免疫功能中的独特作用，揭示了内源性TGF-β 1与正常伤口愈合过程的相关性，并扩展了TGF-β 1活性的已知机制列表以包括内分泌功能。因此，TGF-β 1缺陷小鼠允许定义同种型特异性活性，这为观察TGF-β 1在体内的主要功能提供了一个宝贵的窗口。
A remarkable range of activities has been ascribed to the family of proteins known as transforming growth factor-beta (TGF-beta). Each plays an important role in development and homeostasis, influencing mesenchymal-epithelial interactions, regulating cellular differentiation, and maintaining control of cell proliferation, Although in vitro comparisons of activity demonstrate a high degree of functional similarity, recent studies of mice with a targeted deletion of the TGF-beta 1 gene reveal that true isoform-specific activities do exist in vivo and that the three mammalian isoforms are not functionally redundant, This approach has defined a unique role for TGF-beta 1 in the establishment and maintenance of normal immune function, shed new Light on the relevance of endogenous TGF-beta 1 to the normal wound healing process, and expanded the list of known mechanisms of TGF-beta 1 activity to include endocrine functions, Thus, the TGF-beta 1-deficient mouse allows the definition of isoform-specific activities, providing an invaluable window through which to view the principal functions of TGF-beta 1 in vivo.