Low-Frequency Conductivity Tensor Imaging of the Human Head In Vivo Using DT-MREIT: First Study.
Low-Frequency Conductivity Tensor Imaging of the Human Head In Vivo Using DT-MREIT: First Study.
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DOI：
10.1109/tmi.2017.2783348
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发表时间：
2018-04
影响因子：
10.6
通讯作者：
Sadleir RJ
中科院分区：
文献类型：
--
作者：
Chauhan M;Indahlastari A;Kasinadhuni AK;Schar M;Mareci TH;Sadleir RJ
我们首次展示了人体头部各向异性电导率分布的活体图像，测量频率约为10赫兹。我们使用磁共振电阻抗断层成像(MREIT)技术来编码通过两个独立的电极对在头部内流动的电流引起的相位变化。然后，将这些结果与扩散张量成像数据相结合，重建了两名参与者5毫米厚脑片中的完全各向异性电导率分布。研究中恢复的电导值与文献值大体一致。我们预计这项技术将在神经科学的许多领域中使用，最重要的是通过反向脑电进行功能成像。未来的研究将涉及脉冲序列加速，以最大限度地提高大脑覆盖率和分辨率。
We present the first in vivo images of anisotropic conductivity distribution in the human head, measured at a frequency of approximately 10 Hz. We used Magnetic Resonance Electrical Impedance Tomography (MREIT) techniques to encode phase changes caused by current flow within the head via two independent electrode pairs. These results were then combined with diffusion tensor imaging data to reconstruct full anisotropic conductivity distributions in 5 mm-thick slices of the brains of two participants. Conductivity values recovered in the study were broadly consistent with literature values. We anticipate this technique will be of use in many areas of neuroscience, most importantly in functional imaging via inverse electroencephalogram. Future studies will involve pulse sequence acceleration to maximize brain coverage and resolution.