Age- and Sodium-Sensitive Hypertension and Sex-Dependent Renal Changes in Rats With a Reduced Nephron Number
Age- and Sodium-Sensitive Hypertension and Sex-Dependent Renal Changes in Rats With a Reduced Nephron Number
复制标题
肾单位数量减少大鼠的年龄和钠敏感性高血压和性别依赖性肾脏变化
作者：
F. Salazar;V. Reverte;Fara Saez;A. Loria;M. T. Llinás;F. Salazar;Javier Salazar
我们已经证明，在肾脏形成期间血管紧张素II作用的减少减少了肾单位的数量，并诱导了高血压的发展。研究的假设是，这种血管紧张素作用的减少会导致年龄依赖的钠敏感型高血压的发展，并且高血压是血管紧张素II依赖的。新生大鼠在出生后头两周接受血管紧张素II 1型受体拮抗剂治疗。在3到4个月和11到12个月大时，研究了长期高钠摄入量对血压、蛋白尿和肾功能的影响。两个年龄组的基础血压对血管紧张素II受体拮抗剂的应用也进行了评估。雄鼠和雌鼠的基础血压也同样升高(P<；0.05)，且这种升高与年龄相关。在11至12个月时，高钠摄入仅引起血压升高(136±1至154±3 mm Hg；P<；0.05)和肾小球滤过率下降(28%；P<；0.05)。在肾脏发育过程中阻断血管紧张素II受体可引起与年龄和性别相关的蛋白尿增加(P<；0.05)，但高钠摄入量仅导致年轻大鼠蛋白尿增加(50%；P<；0.05)。高血压在两个年龄段都是由血管紧张素II维持的，因为在使用血管紧张素II 1型受体拮抗剂治疗后，血压下降到正常水平。这项研究表明，肾形成期间血管紧张素II效应的减少改变了肾功能，并诱导了血管紧张素II依赖型高血压的发展，随着年龄的增长，高血压变得对钠敏感。
We have demonstrated that the reduction of angiotensin II effects during the nephrogenic period reduces the nephron number and induces the development of hypertension. The hypotheses examined are that this reduction of angiotensin effects leads to the development of an age-dependent sodium sensitive hypertension and that the hypertension is angiotensin II dependent. Newborn rats were treated with an angiotensin II type 1 receptor antagonist during the first 2 weeks of age. At 3 to 4 and 11 to 12 months of age, changes in systolic blood pressure, proteinuria, and renal function in response to a prolonged high sodium intake were examined. The basal blood pressure response to the administration of the angiotensin II receptor antagonist was also evaluated at both ages. Basal blood pressure was similarly elevated (P<0.05) in male and female treated rats, and the increment was age dependent. High sodium intake only elicited a blood pressure elevation (136±1 to 154±3 mm Hg; P<0.05) and a decrease in glomerular filtration rate (28%; P<0.05) at 11 to 12 months in treated rats. Blockade of angiotensin II receptors during renal development induced an increase (P<0.05) in proteinuria that was age and sex dependent, but high sodium intake only induced an elevation in proteinuria in the younger rats (50%; P<0.05). Hypertension was maintained by angiotensin II at both ages because blood pressure decreased to normal levels after treatment with an angiotensin II type 1 receptor antagonist. This study shows that the reduction of angiotensin II effects during the nephrogenic period modifies renal function and induces the development of an angiotensin II–dependent hypertension that becomes sodium sensitive during aging.
一氧化氮在调节狗肾小球前和肾小球后血管中血管紧张素 II 的血管收缩作用中的作用。
DOI：
10.1161/01.hyp.26.6.1024
发表时间：
1995
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Schnackenberg,CG;Wilkins,FC;Granger,JP
通讯作者：
Granger,JP
血管紧张素II的肾小管作用。
DOI：
--
发表时间：
1987
期刊：
Kidney international. Supplement
影响因子：
--
作者：
Navar,LG;Carmines,PK;Huang,WC;Mitchell,KD
通讯作者：
Mitchell,KD