Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome
Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome
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DOI：
10.1136/gut.51.suppl_1.i67
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发表时间：
2002-07-01
期刊：
影响因子：
24.5
通讯作者：
Delvaux, M
中科院分区：
文献类型：
--
作者：
Delvaux, M
内脏高敏感性已被认为是肠易激综合征(IBS)患者的特征。它可能与腹痛/不适的发病机制有关，并且似乎是源于胃肠道的神经传入通路的敏感性所致。从临床的角度来看，虽然过敏是常见的，但在IBS患者中并不是经常发现的，因此不能被认为是这种情况的诊断标志。本文综述了肠易激综合征患者内脏高敏感性的研究进展：确定了影响腹胀的因素，并对不同的治疗角度进行了探讨。
Visceral hypersensitivity has been recognised as a characteristic of patients with irritable bowel syndrome (IBS). It may be involved in the pathogenesis of abdominal pain/discomfort, and seems to result from the sensitisation of nerve afferent pathways originating from the gastrointestinal tract. From a clinical point of view, hypersensitivity, although frequent, is not a constant finding among patients with IBS and cannot therefore be considered as a diagnostic marker of the condition. The advances made in understanding visceral hypersensitivity in patients with IBS are reviewed: the factors that influence abdominal distension are defined and different therapeutic perspectives are examined.