LOCAL ACTIVATION VARIABILITY DURING MONOMORPHIC VENTRICULAR-TACHYCARDIA IN THE DOG
LOCAL ACTIVATION VARIABILITY DURING MONOMORPHIC VENTRICULAR-TACHYCARDIA IN THE DOG
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DOI：
10.1093/cvr/26.3.237
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发表时间：
1992-03-01
影响因子：
10.8
通讯作者：
GARAN, H
中科院分区：
文献类型：
--
作者：
ROSENBAUM, DS;WILBER, DJ;GARAN, H
目的：目的是确定在实验性心肌梗死犬模型中持续性单形性室性心动过速期间局部激动时间的搏动变异性。研究方法：开发了一种数字模板匹配算法，用于检测多个心室部位中每个部位的局部激动定时中的细微搏动间变异性。10次电诱导持续性室性心动过速发作。平均周期长度为211（SD 40）ms，在体重15-20 kg的杂种狗中进行心内膜和心外膜标测。分析数字化数据的搏动间局部激动时间变异性。在心室起搏期间以可比速率记录的类似数据和在窦性心律期间记录的类似数据作为对照。结果如下：所有10例室性心动过速的局部激动时间的总体平均变异性为3.2（1.6）ms，范围为1.8（1.1）ms至4.7（2.8）ms，相比之下，心室起搏的总体平均变异性为0.2（0.4）ms（p = 0.0001），窦性心律为0.7（0.6）ms（p = 0.0001）。10例室性心动过速中有7例的局部激动时间振荡表现为交替型周期性，与局部电图形态中的任何交替无关。结论：在持续性单形性室性心动过速期间，局部激动时间的逐搏变异性和交替型振荡很常见，并且可能是折返的固有特性，因为它们在心室起搏期间可忽略不计。
Objective: The aim was to determine the beat to beat variability in local activation time during sustained monomorphic ventricular tachycardia in a canine model of experimental myocardial infarction. Methods: A digital template matching algorithm was developed for detecting subtle beat to beat variability in local activation timing at each of multiple ventricular sites. Ten electrically induced sustained ventricular tachycardia episodes. mean cycle length 211 (SD 40) ms, were endocardially and epicardially mapped in mongrel dogs weighing 15-20 kg. Digitised data were analysed for beat to beat local activation time variability. Similar data recorded during ventricular pacing at comparable rates and during sinus rhythm served as controls. Results: The overall mean variability of local activation time for all 10 ventricular tachycardias was 3.2(1.6) ms, range 1.8(1.1) ms to 4.7(2.8) ms, in contrast to the overall mean variability of 0.2(0.4) ms (p = 0.0001) for ventricular pacing and 0.7(0.6) ms (p = 0.0001) for sinus rhythm. Oscillations in local activation time manifested alternans type periodicity during seven of 10 ventricular tachycardias independent of any alternans in local electrogram morphology. Conclusions: During sustained, monomorphic ventricular tachycardia, beat to beat variability and alternans type oscillations in local activation time are common and may be an intrinsic property of re-entry since they are negligibly small during ventricular pacing.