Infralimbic parvalbumin neural activity facilitates cued threat avoidance.
Infralimbic parvalbumin neural activity facilitates cued threat avoidance.
复制标题
边缘下小白蛋白神经活动有助于提示威胁规避。
DOI：
10.1101/2023.08.18.553864
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Warden,MelissaR
中科院分区：
文献类型：
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作者：
Ho,Yi-Yun;Yang,Qiuwei;Boddu,Priyanka;Bulkin,DavidA;Warden,MelissaR
腹内侧前额皮质（vmPFC）对于调节反应性反应和适应性反应之间的平衡至关重要。反应性的、固有的行为——比如冻结或逃跑——在某些情况下是可行的，但在其他情况下，后天的适应性行为可能更有效。尽管 vmPFC 与适应性威胁规避有关，但具有不同分子身份和接线模式的不同 vmPFC 神经亚型的贡献却知之甚少。在这里，我们研究了小鼠的 vmPFC 小白蛋白 (PV) 中间神经元，因为它们学会了穿过一个房间以避免即将到来的电击，这种行为需要学习、适应性行动和抑制提示冻结。我们发现，当竞争性冻结反应被抑制时，vmPFC PV 神经活动在运动时增加以避免电击。然而，在没有竞争行为的情况下，神经活动在朝向提示奖励的运动或一般运动期间并没有改变。 vmPFC PV 神经元的光遗传学抑制延迟了回避行为的发生并增加了冻结的持续时间，但不影响奖励运动或一般运动。因此，vmPFC PV 神经元通过抑制优势行为反应的表达来支持灵活的适应性行为。
The ventromedial prefrontal cortex (vmPFC) is essential for regulating the balance between reactive and adaptive response. Reactive, hard-wired behaviors – such as freezing or flight – are feasible in some situations, but in others contexts an acquired, adaptive action may be more effective. Although the vmPFC has been implicated in adaptive threat avoidance, the contribution of distinct vmPFC neural subtypes with differing molecular identities and wiring patterns is poorly understood. Here, we studied vmPFC parvalbumin (PV) interneurons in mice as they learned to cross a chamber in order to avoid an impending shock, a behavior that requires both learned, adaptive action and the suppression of cued freezing. We found that vmPFC PV neural activity increased upon movement to avoid the shock, when the competing freezing response was suppressed. However, neural activity did not change upon movement toward cued rewards or during general locomotion, conditions with no competing behavior. Optogenetic suppression of vmPFC PV neurons delayed the onset of avoidance behavior and increased the duration of freezing, but did not affect movement toward rewards or general locomotion. Thus, vmPFC PV neurons support flexible, adaptive behavior by suppressing the expression of prepotent behavioral reactions.