Volumetric Alterations in the Nucleus Accumbens and Caudate Nucleus in Bulimia Nervosa: A Structural Magnetic Resonance Imaging Study
Volumetric Alterations in the Nucleus Accumbens and Caudate Nucleus in Bulimia Nervosa: A Structural Magnetic Resonance Imaging Study
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DOI：
10.1002/eat.22273
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发表时间：
2015-03-01
影响因子：
5.5
通讯作者：
Sampaio, Adriana
中科院分区：
文献类型：
--
作者：
Coutinho, Joana;Ramos, Ana Filipa;Sampaio, Adriana
神经性贪食症（BN）是一种饮食失调，其特征是反复发作的暴饮暴食和不适当的补偿行为（如清除，禁食或过度运动），以防止体重增加。BN与抑制性控制过程中的缺陷有关。基底神经节，具体地说，脑桥核（NAc）和尾状核（CN）是参与抑制控制的额纹状体回路的一部分。本研究的主要目标是调查存在的形态学改变的NAC和CN的样本中诊断为BN. MethodForty一名女性参与者，21诊断为BN和20名健康匹配的对照（HC），进行了结构磁共振成像（MRI）收购和临床评估。NAc和CN手动分割使用软件Slicer 3D.ResultsThe结果显示一个显着的体积减少CN和保存NAc体积BN相比，对照组。DiscussionThese研究结果表明，BN的精神病理学的背侧纹状体的尾状核部分的贡献作用。(c)2014年威利期刊公司(Int J Eat Disord 2015; 48：206-214）
ObjectiveBulimia nervosa (BN) is an eating disorder characterized by recurrent episodes of binge eating and inappropriate compensatory behaviors (such as purging, fasting, or excessive exercise) to prevent weight gain. BN has been associated with deficits in inhibitory control processes. The basal ganglia specifically, the nucleus accumbens (NAc) and the caudate nucleus (CN) are part of the frontostriatal circuits involved in inhibitory control. The main goal of this study was to investigate the presence of morphological alterations in the NAc and the CN in a sample of patients diagnosed with BN.MethodForty-one female participants, 21 diagnosed with BN and 20 healthy matched controls (HC), underwent a structural magnetic resonance imaging (MRI) acquisition and clinical assessment. The NAc and the CN were manually segmented using the software Slicer 3D.ResultsThe results reveal a significant volumetric decrease in the CN and a preserved NAc volume in BN compared to the control group.DiscussionThese findings suggest a contributory role of the caudate nucleus part of the dorsal striatum in the psychopathology of BN. (c) 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:206-214)