Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse.
Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse.
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使用细胞木马马将纳米颗粒传递到乳腺癌的脑转移量。
DOI：
10.1007/s12645-012-0029-9
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发表时间：
2012-12
影响因子：
5.7
通讯作者：
Clare SE
中科院分区：
文献类型：
--
作者：
Choi MR;Bardhan R;Stanton-Maxey KJ;Badve S;Nakshatri H;Stantz KM;Cao N;Halas NJ;Clare SE
随着系统性癌症治疗的改善，并能够控制中枢神经系统外的转移性疾病，大脑越来越多地成为复发的第一个部位。血脑屏障（BBB）代表了向脑递送治疗剂的主要挑战。源自循环单核细胞的巨噬细胞能够在BBB完整时浸润脑转移瘤。在这里，我们表明，这种能力可以被利用来提供诊断和治疗纳米粒子专门用于实验性乳腺癌脑转移。
As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood–brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer.