Proton magnetic resonance spectroscopy of patients with parkinsonism
Proton magnetic resonance spectroscopy of patients with parkinsonism
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DOI：
10.1016/s0361-9230(00)00321-x
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发表时间：
2000-08-01
影响因子：
3.8
通讯作者：
Yanagihara, T
中科院分区：
文献类型：
--
作者：
Abe, K;Terakawa, H;Yanagihara, T
我们研究了82名非家族性帕金森综合征患者的脑代谢，包括帕金森病（PD; n = 23），进行性核上性麻痹（PSP; n = 12），皮质基底节变性（CBD; n = 19），多发性系统性萎缩（MSA; n = 18）和血管性帕金森综合征（VP; n = 10），采用质子磁共振波谱（H-1-MRS），其允许非侵入性地测量来自N-乙酰丙酸（NAA）、含胆碱化合物（CHO）和肌酸加磷酸肌酸（CRE）的信号强度。与正常对照组相比，PSP、CBD、MSA和VP（但不包括PD）患者额叶皮质的NAA/CRE比率显着降低，而PSP、CBD、MSA和PD（但不包括VP）患者的NAA/CRE比率显着降低壳核中的CRE比率。与PD、MSA和VP患者相比，CBD患者额叶皮层和壳核的NAA/ CRE比值显著降低。与PD和MSA患者相比，PSP患者的壳核中NAA/CRE比值显著降低。与对照组和其他患者相比，CBD患者的壳核显示出明显的不对称性。壳核中NAA/CRE比值的降低与帕金森综合征的严重程度密切相关。H-1-MRS可用于监测各种类型的帕金森综合征患者。(C)2000 Elsevier Science Inc.
We studied cerebral metabolism in 82 patients with nonfamilial parkinsonism, including Parkinson's disease (PD; n = 23), progressive supranuclear palsy (PSP; n = 12), cortico-basal degeneration (CBD; n = 19), multiple systemic atrophy (MSA; n = 18) and vascular parkinsonism (VP; n = 10) by using proton magnetic resonance spectroscopy (H-1-MRS), which allowed noninvasive measurement of signal intensities from N-acetylasparate (NAA), choline-containing compounds (CHO) and creatine plus phosphocreatine (CRE). As compared to normal controls, patients with PSP, CBD, MSA and VP, but not PD, had significant reduction of the NAA/CRE ratio in the frontal cortex, whereas patients with PSP, CBD, MSA and PD, but not VP, had significant reduction of the NAA/CRE ratio in the putamen. Patients with CBD had significant reduction of the NAA/ CRE ratio in the frontal cortex and putamen as compared to patients with PD, MSA and VP. Patients with PSP showed a significant reduction of the NAA/CRE ratio in the putamen as compared with patients with PD and MSA. Patients with CBD showed clear asymmetry in the putamen as compared to controls and other patients. The reduction of the NAA/CRE ratio in the putamen correlated well with the severity of parkinsonism. H-1-MRS may be useful in monitoring patients with various types of parkinsonism. (C) 2000 Elsevier Science Inc.